Peri-operative data on the nuss procedure in children with pectus excavatum: independent survey of the first 20 years' data
© Protopapas and Athanasiou; licensee BioMed Central Ltd. 2008
Received: 20 March 2008
Accepted: 04 July 2008
Published: 04 July 2008
To review the literature and assess the cumulative data on the Nuss operation in children on its twenty years' anniversary: The Nuss procedure corrects the pectus excavatum by minimal access semi-permanent insertion of metal bars in order to reduce the deformity and refashion the contour of the growing thorax. The advantage over previous techniques is avoidance of osteochondrotomies and thence allowance for normal growth of the thorax.
PubMed search was performed. Primary outcomes were mortality, morbidity and individual complications. Secondary outcomes were procedure time and hospital stay.
We merged the data from 19 reports comprising 1949 children of mean age 10.6 years.
No mortality was observed and the procedure was associated with morbidity of 15.4%. The commonest complications are bar-related adverse events (5.7%) and pneumothorax (3.5%). The average procedure time and the average hospital stay were 68 minutes and 5.5 days respectively.
20 years of initial evidence suggests that the Nuss group of procedures is a safe minimal access option for correction of pectus excavatum in childhood.
The cardiothoracic surgeons are moving towards minimally invasive techniques. Such a technique is the Nuss repair (alias Minimally Invasive Repair of Pectus Excavatum or Miniature Access Pectus Excavatum Repair) for pectus excavatum (funnel chest) , the commonest chest wall anomaly in humans , first described in 1594 by Johannes Schenk, occurring in approximately 1 in every 400 births, males being afflicted 5 times more often than females. The indication for correction is primarily cosmetic, although the potential for cardiorespiratory improvement can be considered.
The original Nuss technique has being previously described [1, 24]. Its principle is the permanent reduction of the bone deformity by insertion of one (or more) malleable metal bars in order to refashion the contour of the growing thorax.
Perceived advantages and disadvantages of minimal access strategy for correction of pectus in childhood in comparison to pre-existing conventional techniques
Short hospital stay
Cost of thoracoscopy and equipment
Second procedure for bar removal
Allowance for skeletal growth
Capnothorax in thoracoscopy
The principal advantage over these techniques is avoidance of osteochondrotomies and thence allowance for normal growth of the thorax, as subperichondral resection of the costal cartilages may halt the growth of the thoracic cage in toddlers and adolescents.
The metalwork is later removed as a day-case operation (nor requiring overnight stay in hospital) under general anaesthesia.
The Nuss operation can be performed with or without use of thoracoscopy. The selection of age for the Nuss varies with clinical, personal and socio-economical reasons (such as change of school and fear of intimidation by new peers), while removal of bars is scheduled within two to three years from the insertion. In Britain, some surgeons prefer to perform Nuss around the age of 10, before the child changes schools and thence is exposed to new peers. Some other surgeons will perform Nuss earlier, deciding on parental preference and individual clinical circumstances.
Materials and methods
We searched the literature with a simple strategy :
Last Date performed: 31 December 2006
Search keyword ‘Nuss’, language English, Humans, children
Cross-validation by hand search to identify case series and exclude isolated case reports.
Primary outcomes: Mortality, morbidity, individual complications
Secondary outcomes: Procedure time and hospital stay.
Descriptive and summary statistics were performed. Denominators were related to actual data. Missing data were not defaulted.
Selection of reports
18 series of Nuss on children were identified (Table 2), originating from one or more of seven countries, or one of five of the United States of America.
The series merged, 20 years of Nuss operations in children 1987–2006
Type of study
Series update on ref. 24
Encompasses ref. 19
Subgroup of all-age cohort
Similar data to ref. 9
Similar data to ref. 8
Same centre as ref. 18
Same centre as ref. 17
Of these, there were at least three reports preceded by others with apparently overlapping cohorts,  by [20, 3] by  and [14, 5] by  so we utilised data from the larger and more up to date ones [2, 3, 5].
Interestingly, two reports from neighbouring countries [Japan, South Korea, [8, 9]) over a similar period had the same number of subjects (107 each), similar but not identical demographics (age, gender) and similar outcomes. Both reports have being included separately in our survey. Two reports from the same centre seemed to report on separate cohorts [17, 18] and have being also included separately in our survey.
Demographics (Table 3)
Cumulative perioperative data on 20 years of Nuss operations in children 1987–2006
1949 children have had Nuss operations. Mean age was 10.6 years, ratio male: female 77:23.
Morbidity and Mortality
Bar-related events (bar displacement requiring revision) (111 events, incidence 5.7%) and
Pneumothorax (68 events including those treated without chest drain, overall incidence 3.5%).
Complications of 20 years of Nuss operations in children 1987–2006
Bar-related adverse events
Other Pleuropulmonary, except pneumothorax
Other Perioperative Data
The average length of operation in minutes was 68 minutes (range 28–200).
Average Hospital stay was 5.5 days (range 2–27 days).
We hope that this brief independent survey will offer the necessary peri-operative data on this now well-established cosmetic intervention in children: The Nuss procedure has been performed all around the world with no reported mortality for 20 years (1987–2007), indicated primarily for cosmesis in the paediatric sufferer of pectus excavatum. Potential cardiorespiratory improvement is not as yet confirmed, whilst the co-existence of Marfan's syndrome can be ruled out by pre-operative echocardiography.
The variations of the Nuss procedure stem from thoracoscopic or open, and then thoracoscopy with single or double-lumen ventilation (in toddlers double lumen ventilation may be cumbersome given their tracheal size). Bar stabilisers have evolved as a valid addition to the technique .
Pneumothorax and bar-related events (pain, dislocation or infection) may complicate the procedure and are the primary post operative points of concern. Pneumothorax is as expected, commoner with thoracoscopy: the technique may involve carbon dioxide insufflation (capnothorax  where single lumen tracheal intubation is utilised.
The advantages of this procedure include the following: the short hospital stay and limited invasion surgery which allows for growth in the skeleton as opposed to the ostochondrectomies (Table 1). On the balance is the obvious cost of the thoracoscopy and specialised equipment as well as the second outpatient-day case procedure of removal of the bar(s).
We have now reached the point of adequate experience with Nuss that the purchasers may decide on strategies after careful individual cost-effectiveness assessment. Most workers timed the operation at an age appropriate to the cosmetic expectations of the patient and family considering the growth spurt of teenagers, namely prior to the early teens. It is not unusual to perform Nuss in young adults as a matter of surgeon's and patient's preference, where care should be exercised for the bar recipient not to be exposed to vigorous activity prior to removal of the bar as displacement is a recognised complication associated with contact sports, trauma or intense manual labour.
Limitations of the study and future research
Not all reported series include the data for the variables studied, the length of postoperative in-hospital stay being one important one. This might have an impact on the results. Post operative hospital stay is a surrogate index of performance, especially in paediatric populations. It is evident in the literature that the available data have not been based in comparative high quality studies and patient based outcomes such as Health Related Quality of life and patient satisfaction which are important considerations in therapeutic decision making. Also the long-term results of the procedure are not being discussed in this paper.
- Nuss D, Croitoru DP, Kelly RE, Goretsky MJ, Nuss KJ, Gustin TS: Review and discussion of the complications of minimally invasive pectus excavatum repair. Eur J Pediatr Surg. 2002, 12 (4): 230-4. 10.1055/s-2002-34485.View ArticlePubMedGoogle Scholar
- Huddleston CB: Pectus excavatum. Semin Thorac Cardiovasc Surg. 2004, 16: 225-32. 10.1053/j.semtcvs.2004.08.003.View ArticlePubMedGoogle Scholar
- Boehm RA, Muensterer OJ, Till H: Comparing minimally invasive funnel chest repair versus the conventional technique: an outcome analysis in children. Plast Reconstr Surg. 2004, 114 (3): 668-73. 10.1097/01.PRS.0000130938.87402.B0. discussion 674–5.View ArticlePubMedGoogle Scholar
- Zallen GS, Glick PL: Miniature access pectus excavatum repair: Lessons we have learned. J Pediatr Surg. 2004, 39 (5): 685-9. 10.1016/j.jpedsurg.2004.01.046.View ArticlePubMedGoogle Scholar
- Park HJ, Lee SY, Lee CS: Complications associated with the Nuss procedure: analysis of risk factors and suggested measures for prevention of complications. J Pediatr Surg. 2004, 39: 391-5. 10.1016/j.jpedsurg.2003.11.012.View ArticlePubMedGoogle Scholar
- Watanabe A, Watanabe T, Obama T, Ohsawa H, Mawatari T, Ichimiya Y: The use of a lateral stabilizer increases the incidence of wound trouble following the Nuss procedure. Ann Thorac Surg. 2004, 77 (1): 296-300. 10.1016/S0003-4975(03)01335-3.View ArticlePubMedGoogle Scholar
- Ohno K, Morotomi Y, Ueda M, Yamada H, Shiokawa C, Nakaoka T: Comparison of the Nuss procedure for pectus excavatum by age and uncommon complications. Osaka City Med J. 2003, 49 (2): 71-6.PubMedGoogle Scholar
- Jo WM, Choi YH, Sohn YS, Kim HJ, Hwang JJ, Cho SJ: Surgical treatment for pectus excavatum. J Korean Med Sci. 2003, 18: 360-4.View ArticlePubMedPubMed CentralGoogle Scholar
- Uemura S, Nakagawa Y, Yoshida A, Choda Y: Experience in 100 cases with the Nuss procedure using a technique for stabilization of the pectus bar. Pediatr Surg Int. 2003, 19 (3): 186-9.PubMedGoogle Scholar
- Haecker FM, Bielek J, von Schweinitz D: Minimally invasive repair of pectus excavatum (MIRPE) – the Basel experience. Swiss Surg. 2003, 9 (6): 289-95. 10.1024/1023-93220.127.116.119.View ArticlePubMedGoogle Scholar
- Schaarschmidt K, Kolberg-Schwerdt A, Dimitrov G, Straubeta J: Submuscular bar, multiple pericostal bar fixation, bilateral thoracoscopy: A modified Nuss repair in adolescents. J Pediatr Surg. 2002, 37 (9): 1276-80. 10.1053/jpsu.2002.34982.View ArticlePubMedGoogle Scholar
- Hosie S, Sitkiewicz T, Petersen C, Gobel P, Schaarschmidt K, Till H: Minimally invasive repair of pectus excavatum – the Nuss procedure. A European multicentre experience. Eur J Pediatr Surg. 2002, 12 (4): 235-8. 10.1055/s-2002-34486.View ArticlePubMedGoogle Scholar
- Jacobs JP, Quintessenza JA, Morell VO, Botero LM, van Gelder HM, Tchervenkov CI: Minimally invasive endoscopic repair of pectus excavatum. Eur J Cardiothorac Surg. 2002, 21 (5): 869-73. 10.1016/S1010-7940(02)00069-6.View ArticlePubMedGoogle Scholar
- Miller KA, Woods RK, Sharp RJ, Gittes GK, Wade K, Ashcraft KW: Minimally invasive repair of pectus excavatum: a single institution's experience. Surgery. 2001, 130 (4): 652-7. 10.1067/msy.2001.116917. discussion 657–9.View ArticlePubMedGoogle Scholar
- Hebra A, Gauderer MW, Tagge EP, Adamson WT, Othersen HB: A simple technique for preventing bar displacement with the Nuss repair of pectus excavatum. J Pediatr Surg. 2001, 36 (8): 1266-8. 10.1053/jpsu.2001.25791.View ArticlePubMedGoogle Scholar
- Wu PC, Knauer EM, McGowan GE, Hight DW: Repair of Pectus Excavatum Deformities in Children: A New Perspective of Treatment Using Minimal Access Surgical Technique. Arch Surg. 2001, 136 (4): 419-424. 10.1001/archsurg.136.4.419.View ArticlePubMedGoogle Scholar
- Molik KA, Engum SA, Rescorla FJ, West KW, Scherer LR, Grosfeld JL: Pectus excavatum repair: experience with standard and minimal invasive techniques. J Pediatr Surg. 2001, 36 (2): 324-8. 10.1053/jpsu.2001.20707.View ArticlePubMedGoogle Scholar
- Engum S, Rescorla F, West K, Rouse T, Scherer LR, Grosfeld J: Is the grass greener? Early results of the Nuss procedure. J Pediatr Surg. 2000, 35 (2): 246-51. 10.1016/S0022-3468(00)90018-6.View ArticlePubMedGoogle Scholar
- Park HJ, Lee SY, Lee CS, Youm W, Lee KR: The Nuss procedure for pectus excavatum: evolution of techniques and early results on 322 patients. Ann Thorac Surg. 2004, 77 (1): 289-95. 10.1016/S0003-4975(03)01330-4.View ArticlePubMedGoogle Scholar
- Croitoru DP, Kelly RE, Goretsky MJ, Lawson ML, Swoveland B, Nuss D: Experience and modification update for the minimally invasive Nuss technique for pectus excavatum repair in 303 patients. J Pediatr Surg. 2002, 37 (3): 437-45. 10.1053/jpsu.2002.30851.View ArticlePubMedGoogle Scholar
- Hebra A, Swoveland B, Egbert M, Tagge EP, Georgeson K, Othersen HB: Outcome analysis of minimally invasive repair of pectus excavatum: review of 251 cases. J Pediatr Surg. 2000, 35 (2): 252-7. 10.1016/S0022-3468(00)90019-8.View ArticlePubMedGoogle Scholar
- Dzielicki J, Korlacki W, Janicka I, Dzielicka E: Difficulties and limitations in minimally invasive repair of pectus excavatum-6 years experiences with Nuss technique. Eur J Cardiothorac Surg. 2006, 30 (5): 801-4. 10.1016/j.ejcts.2006.08.004.View ArticlePubMedGoogle Scholar
- Kim DH, Hwang JJ, Lee MK, Lee DY, Paik HC: Analysis of the Nuss Procedure for Pectus Excavatum in Different Age Groups. Ann Thorac Surg. 2005, 80 (3): 1073-7. 10.1016/j.athoracsur.2005.03.070.View ArticlePubMedGoogle Scholar
- Nuss D: Recent experiences with minimally invasive pectus excavatum repair "Nuss procedure". Jpn J Thorac Cardiovasc Surg. 2005, 53: 338-44.View ArticlePubMedGoogle Scholar
- Peden CJ, Prys-Roberts C: Capnothorax: Implications for the anaesthetist. Anaesthesia. 1991, 48: 664-6. 10.1111/j.1365-2044.1993.tb07174.x.View ArticleGoogle Scholar
- Schalamon J, Pokall S, Windhaber J, Hoellwarth M: Minimally invasive correction of pectus excavatum in adult patients. J Thorac Cardiovasc Surg. 2006, 132 (3): 524-9. 10.1016/j.jtcvs.2006.04.038.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.