Difference between pre-operative and cardiopulmonary bypass mean arterial pressure is independently associated with early cardiac surgery-associated acute kidney injury

Table 3 Univariate Factors associated with early CSA-AKI.

Predictor	Odds Ratio	95% CI	P-value
Male Sex	1.06	0.5-2.1	0.87
Age (per year)	1.01	0.99-1.04	0.25
Age ≥ 75 years (present)	1.7	0.8-3.5	0.15
BMI (kg/m²)(per 1 point)	1.2	0.8-3.5	< 0.0001
BMI ≥25 kg/m² (present)	4.4	1.9-10.2	0.0007
Valve disease (present)	0.55	0.3-1.0	0.06
DM (present)	2.2	1.1-4.2	0.025
PVD (present)	1.9	0.9-3.3	0.19
HTN (present)	1.7	0.9-3.3	0.12
Delta MAP (per 1 mmHg)	1.02	0.99-1.04	0.14
Delta MAP ≥26 mmHg (present)	2.1	1.1-4.2	0.024
Flow ≥54 per mL/kg/min (present)	0.2	0.1-0.5	0.0002
pH	1.4	0.8-2.7	0.26
Pre-operative ACE inhibitor (present)	0.6	0.3-1.1	0.1
Valve Surgery (present)	0.5	0.3-1	0.07
Peak CPB-MAP	0.5	0.2-0.97	0.04
Pre-operative Systolic BP (≥111 mmHg)	2.1	0.99-4.6	0.05
Duration of CPB MAP ≤60 (per 1 min)	1.99	0.9-4.4	0.89

Abbreviations: BMI = Body Mass Index; DM = Diabetes Mellitus PVD = Peripheral Vascular Disease; HTN = Hypertension; MAP = Mean Arterial Pressure; ACE = Angiotensin Converting Enzyme; CPB=Cardiopulmonary Bypass' MAP = mean arterial pressure

ISSN: 1749-8090