Bronchogenic cyst associated with pericardial defect: Case report and review of the literature
© Imperatori et al; licensee BioMed Central Ltd. 2011
Received: 16 February 2011
Accepted: 20 June 2011
Published: 20 June 2011
Partial defect of the pericardium combined with bronchogenic cyst is a very rare congenital anomaly. We describe the case of a 32-year-old man with a partial defect of the left pericardium and a bronchogenic cyst arising from the border of the pericardial defect. The cyst was successfully resected with the harmonic scalpel by three-port videothoracoscopic approach.
KeywordsBronchogenic cyst pericardial defect video-thoracoscopy harmonic scalpel
Mediastinal bronchogenic cysts (BC) are uncommon pathologic entities of congenital origin, representing 12% to 18% of all primary mediastinal masses [1–3]. Although BC are often asymptomatic, they can be complicated by infection, compression of the trachea or superior vena cava, intracystic hemorrhage, rupture, hemoptysis, and malignant changes [4–7].
BC have been reported to be also associated with other congenital malformations, including cardiac and pericardial anomalies [8–21]. Partial or total pericardial defect (PD) associated with BC is a very rare malformation, of which only 19 cases have been reported in the literature.
We present here a case of mediastinal BC associated with partial PD, successfully treated by a video-assisted thoracoscopic surgery (VATS). We also review the literature concerning the clinical presentation and management of BC associated with PD.
BC are the most common cystic lesions of the mediastinum and account for 18% of all primitive mediastinal masses. The prevalence of BC is difficult to ascertain, because they frequently are asymptomatic [5, 23–26]. While most BC are located in the mediastinum, 15% to 30% of them are found within the lung parenchyma; in the latter case the lower lobes are most commonly involved [1–3]. Atypical locations of BC are also reported, including the neck, the spinal dura mater and the diaphragmatic region [1–3]. BC are congenital malformations arising from the primitive foregut with an abnormal division of the tracheobronchial tree; the stage of embryonic development determines the mediastinal location . In case of early separation from the main tracheobronchial tree, BC are located in the mediastinum close to the trachea, carina, main bronchi or esophagus; histologically these entities present ciliated epithelium derived from either the respiratory or the alimentary tract. When the separation occurs late, BC involve the lung parenchyma and the cysts present a lined respiratory epithelium [5, 27]. BC are most frequently unilocular; their fluid content may be clear, or dense and yellow, or hemorrhagic, or mixed with air in case of intrapulmonary location of the cyst.
No clinical presentation is specifically suggestive of BC because these lesions are frequently asymptomatic, their diagnosis being incidental [6, 23]. Chest pain, cough, dyspnea, and dysphagia are reported as possible clinical manifestations of BC, arising from compression of the esophagus and/or major airways [4–7, 23]. In the case we are reporting, the patient was symptomatic for cough and chest pain; the preoperative diagnosis of BC was made by chest radiography and CT scan.
Complete surgical excision is the treatment of BC generally accepted, because these lesions do not spontaneously regress and can enlarge or become infected. Several surgical techniques have been described [5, 23–26, 28]. Drainage of a compressive cyst is a temporary palliative procedure, generally reserved to inoperable patients, to the management of recurrences and of severe compression [5, 29]. Surgical approaches include thoracotomy and VATS [5, 23–26]. In the last decade VATS has emerged for the treatment of BC in absence of severe adhesions to surrounding mediastinal organs [29, 30]. In the present case the mediastinal BC was resected by thoracoscopic approach, using the harmonic scalpel, a technique that has become available in recent years and proved to be safe and effective . Harmonic scalpel confers some advantages over conventional methods of dissection, such as electric cautery, in VATS procedures. It reduces blood loss, duration of drainage and length of the VATS procedure with a comparable cost as compared to electric cautery. Similar advantages of harmonic scalpel have been observed in other surgical fields, such as thyroid surgery , video-assisted thoracoscopic thymic resection  and vascular surgery .
Various congenital anomalies of the heart, lung, chest wall and diaphragm have been reported to be associated with BC. PD, patent ductus arteriosus, atrial septal defect, tetralogy of Fallot, mitral stenosis, pulmonary sequestration and diaphragmatic hernia have been encountered in association with BC [4, 5]. During development of the pleuropericardial fold, pericardial defects and lung anomalies such as bronchogenic cyst may occur together ; this event is unlikely to be co-incidental. In the present case, a partial PD was incidentally discovered during surgery for resection of BC. Congenital PD is a rare anomaly presenting as a complete or partial absence of the pericardium. Partial absence more commonly occurs on the left side (70%) than on the right (17%) or in the inferior portion of the pericardium . The prevalence of PD is likely underestimated, because the symptoms are absent or scarce and the diagnostic criteria are poorly known . It should be emphasized that the intact pericardium over the left atrial appendage is very thin and may not be identified even in normal people; thus, a partial left PD is nearly impossible to be recognized by routine CT scan, unless the atrial appendage is frankly bulging from the defect .
Usually patients with PD are asymptomatic and the diagnosis is incidental during thoracic surgery for unrelated conditions, as in our case.
Atypical angina symptoms or dyspnea are possible unspecific manifestations . Although small defects occasionally induce serious or even lethal complications due to the incarceration of cardiac tissue, large or total left-sided PDs are usually considered benign and deserve no treatment. Surgical repair is required in case of large cardiac herniation and imminent strangulation .
Cases of bronchogenic cyst associated with pericardial defect published in the English language literature
Pericardial defect Location/Extension (cm)
Other congenital anomalies
Rusby and Sellors 
L upper lobe
Jones P. 
L, Partial 3 × 2
L upper lobe
L, Partial (extensive)
R lung apex
R, Partial 4 × 2.5
L upper lobe
L, Partial, 2.5 × 2.5
10 × 6
R lung apex
Double BC, vascular
Warner et al. 
7 1/2, M
2 × 2
L upper lobe
Hamilton LC. 
L lower lobe
Mukerjee S. 
L upper lobe
Kwak et al. 
7.5 × 5 × 3.6
Excision + PDS
L, Partial 2 × 2
Kassner et al. 
6 × 6
L upper lobe
Excision + PDS
L, Partial 2 × 2
Victor and Daniel 
5 × 4
R upper lobe
Excision + PDS
Eom et al. 
8 × 7 × 4.5
Özpolat et al. 
L upper lobe
Chest pain, dysphagia, dyspnea
ASD, MVP, hypospadias
10 × 10
Chest pain, cough
To our knowledge, the case of BC associated to PD presented here is the first described that was treated by VATS approach, using the harmonic scalpel for resecting the cyst. The decision to close the PD can only be made on an individual basis, after evaluation of the specific anatomical alterations. In our case we did not close the partial PD because the left atrial appendage was adherent with the inner aspect of the pericardium and did not herniate; that decision proved to be appropriate, because at 18-month follow-up the transthoracic echocardiography confirmed no cardiac herniation nor functional deficiency.
In conclusion, in the case presented the VATS approach to resect the BC with the harmonic scalpel and the decision to leave the PD open proved to be safe, effective and minimally invasive.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor in Chief of this journal.
- BC :
- PD :
- VATS :
video-assisted thoracoscopic surgery
- CT :
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