Cox-Maze III procedure with valvular surgery in an autopneumonectomized patient
© Wi et al.; licensee BioMed Central Ltd. 2012
Received: 6 August 2012
Accepted: 3 November 2012
Published: 8 November 2012
Destructive pulmonary inflammation can leave patients with only a single functional lung, resulting in anatomical and physiological changes that may interfere with subsequent cardiac surgeries. Such patients are vulnerable to perioperative cardiopulmonary complications. Herein, we report the first case, to our knowledge, of an autopneumonectomized patient who successfully underwent a modified Cox-Maze III procedure combined with valvular repairs. The three major findings in this case can be summarized as follows: (1) a median sternotomy with peripheral cannulations, such as femoral cannulations, can provide an optimal exposure and prevent the obstruction of vision that may occur as a result of multiple cannulations through a median sternotomy; (2) a modified septal incision combined with biatrial incisions facilitate adequate exposure of the mitral valve; and (3) the aggressive use of intraoperative ultrafiltration may be helpful for the perioperative managements as decreasing pulmonary water contents, thereby avoiding the pulmonary edema associated with secretion of inflammatory cytokines during a cardiopulmonary bypass. We also provide several suggestions for achieving similar satisfactory surgical outcomes in patients with a comparable condition.
KeywordsArrhythmia therapy Mitral valve repair Pneumonectomy
Severe destructive lung lesions may form as sequelae of inflammatory pulmonary disease. An extreme sequela is autopneumonectomy, which results in anatomical and physiological changes that can have deleterious effects on subsequent cardiac surgery, especially when multiple procedures are required. Herein, we report our success performing a modified Cox-Maze III procedure combined with valvular surgery in an autopneumonectomized patient.
The patient was extubated 14 hours after the operation. The postoperative course was unremarkable and she was discharged on the 11th postoperative day. At the 11-month follow-up, she had normal sinus rhythm, no mitral regurgitation (pressure gradient: 3.9 mmHg), and mild tricuspid regurgitation; she is currently classified as having NYHA class II heart failure. At the last follow-up, she was prescribed an angiotensin II receptor blocker, diuretics, and bronchodilator medications.
Patients with pulmonary dysfunction are known to be vulnerable to perioperative cardiopulmonary complications. Lethal outcomes may result from even minor atelectasis, congestion, or nasocomial infection. Thus, it can be challenging to treat these patients, and it is important to consider selection criteria, exposure of intracardiac structures, avoidance of the phrenic nerve and remaining lung injuries, and perioperative management. Unfortunately, literature on cardiac surgeries in autopneumonectomized patients is lacking [1, 2]; in order to develop our surgical plan, we had to rely almost completely on reports of cardiac surgeries performed after pneumonectomy.
Our literature review identified several potential methods of determining whether the patient possessed the minimal pulmonary reserve required to avoid dependency on mechanical ventilation after operation; these included a pulmonary function test, an arterial blood gas analysis, and pulmonary artery pressure [3, 4]. Previous authors have recommended that patients not undergo operation if their forced expiratory volume per 1 second is <40% of predicted values and <800 ml, if their resting carbon dioxide tension is >50 mmHg, or if their diffusion capacity of carbon monoxide is >50% of predicted values. Further, surgery is known to be riskier in patients with a mean pulmonary artery pressure >40 mmHg. Judging by these criteria, our patient was only marginally acceptable. However, we decided to proceed with surgery since she had been suffering from acutely progressive symptoms and had maintained an active lifestyle before the onset of symptoms.
An autopneumonectomized lung can displace and rotate the heart into the ipsilateral hemithorax, thereby making exposure cumbersome through the conventional approach. As a result, it may be preferable to use an alternative surgical approach after pneumonectomy . However, it is also feasible to perform median sternotomy, which is a more familiar way to conduct cardiac surgery after pneumonectomy [1, 2, 6]; we decided to perform a median sternotomy with femoral cannulations. We hoped that the use of a median sternotomy with peripheral cannulations would prevent the surgical field from becoming crowded with cannulae; additionally, we anticipated it would improve exposure, since a large number of cannulae and surgical instruments in the operative field would limit a surgeon’s vision from the right side when the heart is severely rotated into the left side. A modified septal incision combined with biatrial incisions also seemed likely to facilitate exposure of the mitral valve, since the left atrial structures were located farther far away from the surgeon’s vision than those on the right (Figure 3).
The Cox-Maze III procedure, which may be modified in a number of ways, is a well-established technique for restoring sinus rhythm in patients with atrial fibrillation combined with mitral valve disease . Cardioversion to sinus rhythm improves hemodynamics and ventilation efficiency . In our opinion, it is important to restore sinus rhythm when pulmonary reserves are diminished, as in the current case. The biatrial Cox-Maze III procedure was successful for our patient, whose heart rhythm has been maintained since the surgery.
This procedure has been associated with injuries to the phrenic nerve and the remaining lung. Diaphragmatic dysfunction can be minimized by avoidance of topical cardiac hypothermia [1, 2, 6]. It is also advisable to avoid use of a Swan-Ganz catheter, and to place the central line on the contralateral side of the normal hemithorax [3, 6]. Additionally, we recommend the aggressive use of intraoperative ultrafiltration (IU), a technique that has been known to remove mediators of inflammation (i.e., cytokines), as well as accumulations of tissue water generated during CPB. IU can be used not only to decrease pulmonary vascular resistance and lung water content, but also to conserve blood and improve PaO2. We also advocate intensive chest physiotherapy, low-pressure ventilation, and early extubation during the perioperative period. Fluid administration should be restricted and adjusted perioperatively depending on volume status. Early postoperative mobilization may also be helpful [1–3].
To the best of our knowledge, this report is the first to describe the use of a modified Cox-Maze III procedure combined with valvular repairs in a case of autopneumonectomized lung. In patients with this condition, all possible measures should be employed to preserve the single functional lung. We especially recommend not only an individualized approach, but also the aggressive use of intraoperative ultrafiltration to reduce lung water content and restore remaining pulmonary function. Our results suggest that, with optimal perioperative and intraoperative management, it is possible to achieve an acceptable outcome following cardiac surgery in autopneumonectomized patients; prior to the procedure, however, patients should be evaluated with appropriate selection criteria and provided with adequate counseling.
Written informed consent was obtained from the patient for publication of this case report and all accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
HM - Is a surgeon of the Thoracic and Cardiovascular Surgery department at the Haeundae Paik Hospital where the patient underwent operation. He is also an assistant professor at the Inje University College of Medicine in Busan, Korea.
- Yazicioglu L, Aral A, Uymaz O, Akalin H: Coronary artery bypass surgery in a patient with a functional single lung. Asian Cardiovasc Thorac Ann. 2005, 13 (4): 377-379. Article within a journalView ArticlePubMedGoogle Scholar
- Wi JH, Yoon YC, Han IY, Jun HJ, Hwang YH, Cho KH: Off-pump coronary artery bypass surgery in a patient with a functional single lung. Korean J Thorac Cardiovasc Surg. 2008, 41: 492-495. Article within a journalGoogle Scholar
- Medalion B, Elami A, Milgalter E, Merin G: Open heart operation after pneumonectomy. Ann Thorac Surg. 1994, 58 (3): 882-884. 10.1016/0003-4975(94)90776-5. Article within a journalView ArticlePubMedGoogle Scholar
- Shanker VR, Yadav S, Hodge AJ: Coronary artery bypass grafting with valvular heart surgery after pneumonectomy. ANZ J Surg. 2005, 75 (1–2): 88-90. Article within a journalView ArticlePubMedGoogle Scholar
- Barreda T, Laali M, Dorent R, Acar C: Left thoracotomy for aortic and mitral valve surgery in a case of mediastinal displacement due to pneumonectomy. J Heart Valve Dis. 2008, 17 (2): 239-242. Article within a journalPubMedGoogle Scholar
- Stoller JK, Blackstone E, Pettersson G, Mihaljevic T: Coronary artery bypass graft and/or valvular operations following prior pneumonectomy: report of four new patients and review of the literature. Chest. 2007, 132 (1): 295-301. 10.1378/chest.06-2545. Article within a journalView ArticlePubMedGoogle Scholar
- Kim KB, Huh JH, Kang CH, Ahn H, Sohn DW: Modifications of the Cox-Maze III Procedure. Ann Thorac Surg. 2001, 71: 816-822. 10.1016/S0003-4975(00)02391-2. Article within a journalView ArticlePubMedGoogle Scholar
- Lundström T, Karlsson O: Improved ventilatory response to exercise after cardioversion of chronic atrial fibrillation to sinus rhythm. Chest. 1992, 102 (4): 1017-1022. 10.1378/chest.102.4.1017. Article within a journalView ArticlePubMedGoogle Scholar
- Grünenfelder J, Zünd G, Schoeberlein A, Maly FE, Schurr U, Guntli S, Fischer K, Turina M: Modified ultrafiltration lowers adhesion molecule and cytokine levels after cardiopulmonary bypass without clinical relevance in adults. Eur J Cardio-thorac Surg. 2000, 17: 77-83. 10.1016/S1010-7940(99)00355-3. Article within a journalView ArticleGoogle Scholar
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