The effect of ulinastatin on acute kidney injury in patients undergoing off-pump cardiac bypass surgery

Table 5 Univariate and multivariate regression analysis for factors affecting Cr1 in patients treated with ulinastatin

	Univariate		Multivariate
	Coefficient ± SE	P value	Coefficient ± SE	P value
Ulinastatin	− 0.049 ± 0.025	0.053	− 0.041 ± 0.017	0.017*
Age (years)	0.0038 ± 0.0011	< 0.001*	0.0032 ± 0.0008	< 0.001*
Sex (Male)	− 0.22 ± 0.03	< 0.001*	− 0.14 ± 0.03	< 0.001*
Hypertension	0.042 ± 0.024	0.088	Eliminated
Diabetes	0.047 ± 0.024	0.052	Eliminated
COPD	0.095 ± 0.119	0.429	Eliminated
EF < 40%	0.107 ± 0.033	0.001*	0.073 ± 0.023	0.001*
Hematocrit	− 0.00039 ± 0.00247	0.876	− 0.00473 ± 0.00182	0.010*
Baseline Creatinine (mg/dL)	0.67 ± 0.04	< 0.001*	0.56 ± 0.04	< 0.001*
Blood loss (mL)	− 0.029 ± 0.038	0.447	Eliminated
Input fluid (mL)	0.00052 ± 0.01108	0.963	Eliminated
Number of Intraoperative hypotension event	0.0086 ± 0.0071	0.002*	Eliminated
RBC transfusion (unit)	0.011 ± 0.010	0.261	Eliminated
Urine (mL)	− 0.060 ± 0.025	0.018*	Eliminated

P value* < 0.05 indicates statistical significance
Cr1 post-operative day 1, COPD Chronic obstructive pulmonary disease, EF Ejection fraction RBC Red blood cell

ISSN: 1749-8090