Table 2 Comparison of histopathological data of cases according to tumor subtype (n = 72)
Adenocarcinoma (n = 33) | SCC (n = 29) | NSCLC (n = 10) | |||||||
|---|---|---|---|---|---|---|---|---|---|
Control group (n = 19) | Study group (n = 14) | P value | Control group (n = 18) | Study group (n = 11) | P value | Control group (n = 2) | Study group (n = 8) | P value | |
Tumor Diameter (mm) \(\bar x\) (Min-Max) | 35 (15–80) | 40 (12–73) | 0.956 | 35.5 (13–65) | 40 (7–55) | 0.421 | 30 (15–45) | 36.5 (5–70) | 0.711 |
Lymph node metastasis, N (%) | 10 (52.6) | 8 (57.1) | 0.797 | 5 (27.8) | 4 (36.4) | 0.943 | 0 (0.0) | 2 (25.0) | 0.429 |
Pleural invasion, N (%) | 3 (15.8) | 2 (14.3) | 0.905 | 2 (11.1) | 0 (0.0) | 0.696 | 1 (50.0) | 3 (37.5) | 0.747 |
Lymphovascular invasion, N (%) | 6 (31.6) | 3 (21.4) | 0.801 | 3 (16.7) | 0 (0.0) | 0.423 | 0 (0.0) | 2 (25.0) | 0.429 |
Fibrosis, N (%) | 15 (78.9) | 12 (85.7) | 0.967 | 7 (38.9) | 11 (100.0) | 0.0038 | 1 (50.0) | 5 (62.5) | 0.747 |
Necrosis, N (%) | 11 (57.9) | 6 (42.9) | 0.616 | 13 (72.2) | 6 (54.5) | 0.569 | 1 (50.0) | 2 (25.0) | 0.490 |
Foreign body reaction, N (%) | 0 (0.0) | 6 (42.9) | 0.007 | 0 (0.0) | 3 (27.3) | 0.087 | 0 (0.0) | 2 (25.0) | 0.429 |
Degree of inflammation, | |||||||||
N (%) | |||||||||
Mild | 6 (31.6) | 3 (21.4) | 9 (50.0) | 6 (54.5) | 1 (50.0) | 2 (25.0) | |||
Moderate | 11 (57.9) | 1 (7.1) | 0.0008 | 8 (44.4) | 3 (27.3) | 0.447 | 1 (50.0) | 3 (37.5) | 0.564 |
Severe | 2 (10.5) | 10 (71.4) | 1 (5.6) | 2 (18.2) | 0 (0.0) | 3 (37.5) | |||
CD4/CD8 ratio | |||||||||
\(\bar x\) (Min-Max) | |||||||||
Intratumoral | 1.13 (0.00-7.13) | 0.74 (0.13–2.67) | 0.469 | 1.52 (0.04–5.60) | 0.77 (0.11-2.00) | 0.0139 | 1.2 (0.33–2.07) | 0.67 (0.22–2.05) | 0.794 |
Peritumoral | 1.47 (0.03–11.42) | 1.37 (1.02–6.50) | 0.702 | 1.66 (0.23–6.76) | 1.17 (0.18–3.85) | 0.173 | 0.59 (0.42–0.75) | 1.60 (0.39–3.35) | 0.267 |
P value | 0.093 | 0.094 | 0.548 | 0.114 | > 0.999 | 0.0499 | |||