The association of regional block with intraoperative opioid consumption in patients undergoing video-assisted thoracoscopic surgery: a single-center, retrospective study

Table 4 The association between type of regional block and intraoperative OME: generalized linear regression

Variable	Mean difference of OME in mg (95% CI)	adjusted P value
Type of regional block
GA	Reference	-
TEA	-78.45 (-141.34 to -15.56)	0.014*
TPVB	-94.92 (154.48 to -35.36)	0.020*
SAPB	-11.47 (-72.07 to 49.14)	0.711
Age per year increase	2.17 (-0.54 to 4.88)	0.117
Female sex (yes vs. no)	-14.76 (-62.83 to 33.30)	0.547
Weight per kg increase	3.11 (0.63 to 5.58)	0.014*
Chronic obstructive pulmonary disease (yes vs. no)	39.76 (-39.12 to 118.64)	0.323
Hypertension (yes vs. no)	-36.32 (-76.93 to 4.30)	0.080
Total intravenous anesthesia (yes vs. no)	65.50 (13.68 to 117.33)	0.013*
Flubiprofen per mg increase	0.21 (-0.37 to 0.78)	0.480
Dexamethasone per mg increase	-2.25 (-6.50 to 2.00)	0.299
Title of anesthesiologist
Registrar	Reference	-
Associate Consultant	-0.34 (-53.86 to 53.18)	0.990
Consultant	23.04 (-55.27 to 101.34)	0.564

These confounders were all entered into a generalized linear regression including: age, sex, weight, TIVA, dexamethasone, flubiprofen, and variables with P < 0.1 in univariate analysis (chronic obstructive pulmonary disease, hypertension, title of anesthesiologist). N = 168. *adjusted P < 0.05
Abbreviations: OME: oral morphine equivalents; CI: confidence interval; GA: General anesthesia without regional block; TEA: Thoracic epidural analgesia combined with general anesthesia; TBVP: Thoracic paravertebral block combined with general anesthesia; SABP: Serratus anterior plane block combined with general anesthesia

ISSN: 1749-8090