Table 4 Comparison of population with and without postoperative hyper-inflammation
Variables | Control (n = 353) | Hyper-inflammation (n = 52) | P value |
|---|---|---|---|
Age(year) | 53.84 ± 13.59 | 57.06 ± 12.30 | 0.107 |
Gender male n (%) | 273 (77.34) | 37 (71.15) | 0.326 |
BMI(kg/m2) | 25.37 (23.32–27.91) | 24.83 (22.20–28.53) | 0.769 |
Medical history n (%) | |||
Hypertension | 387 (95.56) | 338 (95.75) | 0.892 |
Diabetes mellitus | 68 (19.26) | 12 (23.08) | 0.519 |
COPD | 121 (34.28) | 22 (42.31) | 0.258 |
Smoking | 170 (48.16) | 23 (44.23) | 0.596 |
Heavy alcohol drinking | 52 (14.73) | 6 (11.54) | 0.540 |
Liver diseases | 13 (3.68) | 0 (0.00) | 0.325 |
Marfan syndrome | 18 (5.10) | 2 (3.85) | 0.963 |
Cerebral infarction | 16 (4.53) | 1 (1.92) | 0.613 |
Chronic renal failure | 4 (1.13) | 0 (0.00) | 1.000 |
Ascending aortic diameter (cm) | 4.80 (4.40–5.50) | 4.90 (4.50–5.53) | 0.020 |
Pre-operative PCT (ng/ml) | 0.01 (0.01–0.10) | 0.01 (0.01–0.10) | 0.877 |
Pre-operative CRP (mg/L) | 3.52 (1.14–7.77) | 3.92 (1.14–16.10) | 0.596 |
Pre-operative IL-6 (pg/ml) | 34.70 (11.68–52.71) | 39.85 (17.40–107.75) | 0.063 |
Pre-operative SII | 531.84 (153.00–1400.00) | 615.55 (184.46–1400.00) | 0.669 |
Preoperative conditions n (%) | |||
Bowel ischemia | 6 (1.70) | 1 (1.92) | 1.000 |
Cerebral ischemia | 32 (9.07) | 10 (19.23) | 0.025 |
Limb ischemia | 36 (10.20) | 15 (28.85) |  < 0.001 |
Coronary artery involvement | 10 (2.83) | 3 (5.77) | 0.484 |
Arch surgery n (%) | 0.941 | ||
Total arch replacement | 235 (66.57) | 34 (65.38) | Â |
Hemi arch replacement | 48 (13.60) | 8 (15.38) | Â |
Arch stent | 70 (19.83) | 10 (19.23) | Â |
Root surgery n (%) | 0.461 | ||
Bentall procedure | 185 (52.41) | 24 (46.15) | Â |
Wheat’s procedure | 81 (22.95) | 11 (21.15) |  |
Reconstruction | 87 (24.65) | 17 (32.69) | Â |
Concomitant CABG n (%) | 10 (2.83) | 3 (5.77) | 0.484 |
CPB time (min) | 163.00 (140.00–196.00) | 218.00 (195.50–269.00) | < 0.001 |
ACC time (min) | 134.00 (113.00–168.00) | 158.50 (133.75–207.50) | < 0.001 |
DHCA time (min) | 32.00 (25.00–41.00) | 46.00 (38.00–56.25) | < 0.001 |
PCT on POD1 (ng/ml) | 3.04 (2.03–5.48) | 6.34 (3.57–6.90) | < 0.001 |
CRP on POD1 (mg/L) | 79.00 (44.00–113.00) | 104.00 (69.00–125.50) | < 0.001 |
IL-6 on POD1 (pg/ml) | 154.70 (54.62–253.52) | 438.86 (329.28–1039.78) | < 0.001 |
SII on POD1 | 2698.75 (1516.67–4891.25) | 1259.13 (714.77–1692.67) | < 0.001 |
Death | 27 (7.65) | 16 (30.77) | < 0.001 |