Fig. 4

circ_0001786 silencing regulated gefitinib-resistant NSCLC cell colony formation ability, apoptosis and gefitinib sensitivity by targeting miR-34b-5p. PC9-GR and HCC827-GR cells were transfected with si-NC, si-circ (si-circ_0001786), si-circ + inhibitor NC or si-circ + miR-34b-5p inhibitor. (A) miR-34b-5p expression after different treatments. (B-D) Cell viability, colony formation ability and apoptosis were detected by CCK8 (B), colony formation assay (C) and flow cytometry (D) after different treatments. *P < 0.05, **P < 0.01, ***P < 0.001