Table 1 Clinical features of the 258 patients with multiple lung cancers
Patient characteristics | Results | |
|---|---|---|
Age (y), mean ± SD | 60.0 ± 8.0 | |
BMI, mean ± SD | 24.9 ± 6.1 | |
Male, n (%) | 139 (53.9%) | |
Smoker, n (%) | 121 (46.9%) | |
Drinking history, n (%) | 62 (24.0%) | |
Personal history of neoplasia, n (%) | 24 (9.3%) | |
Family history of neoplasia, n (%) | 64 (24.8%) | |
Family history of lung cancer, n (%) | 39 (15.1%) | |
Past medical history, n (%) | 89 (34.5%) | |
Presented symptoms before the first surgery, n (%) | 106 (41.1%) | |
Prime symptoms before the first surgery, n (%) | ||
Cough | 66 (25.6%) | |
Expectoration | 40 (15.5%) | |
Bloody sputum | 20 (7.8%) | |
Chest pain | 14 (5.4%) | |
Fever | 7 (2.7%) | |
Hemoptysis | 4 (1.6%) | |
Number of resected tumors, n (%) | ||
2 | 208 (80.6%) | |
3 | 37 (14.3%) | |
4 | 10 (3.9%) | |
5 | 2 (0.8%) | |
6 | 1 (0.4%) | |
Times the patient underwent surgery, n (%) | ||
1 | 136 (52.7%) | |
2 | 121 (46.9%) | |
3 | 1 (0.4%) | |
Types of multiple cancers (simultaneous/metachronous) | ||
Simultaneous lung cancers | 206 (79.8%) | |
Metachronous lung cancers | 52 (20.2%) | |
Types of surgery (thoracotomy/VATS) | ||
VATS | 100 (38.8%) | |
Thoracotomy | 120 (46.5%) | |
Thoracotomy and VATS | 38 (14.7%) | |
Type(s) of resection of multiple lesions | ||
Lobectomy + sublobar resection | 127 (49.2%) | |
Lobectomy + lobectomy | 54 (20.9%) | |
Sublobar resection + sublobar resection | 36 (14.0%) | |
Lobectomy | 31 (12.0%) | |
Pneumonectomy | 10 (3.9%) | |
Relationship of the locations of multiple lesions | ||
Ipsilateral tumors | 159 (61.6%) | |
Bilateral tumors | 99 (38.4%) | |
Pathological type | ||
Adenocarcinoma | 183 (70.9%) | |
Squamous cell carcinoma | 37 (14.3%) | |
Adenocarcinoma and squamous cell carcinoma | 14 (5.4%) | |
Adenosine carcinoma and adenocarcinoma | 11 (4.3%) | |
Adenocarcinoma and large cell carcinoma | 3 (1.2%) | |
Adenocarcinoma and sarcomatoid carcinoma | 2 (0.8%) | |
Small cell carcinoma | 2 (0.8%) | |
Squamous cell carcinoma and large cell carcinoma | 1 (0.4%) | |
Squamous cell carcinoma and pleomorphic carcinoma | 1 (0.4%) | |
Squamous cell carcinoma and carcinoid | 1 (0.4%) | |
Squamous cell carcinoma and small cell carcinoma | 1 (0.4%) | |
Adenocarcinoma and carcinoid | 1 (0.4%) | |
Adenocarcinoma and inflammatory myofibroblastoma | 1 (0.4%) | |
Location of lesions | ||
Right upper lobe | 187 (32.1%) | |
Left upper lobe | 126 (21.6%) | |
Right inferior lobe | 111 (19.0%) | |
Left inferior lobe | 89 (15.3%) | |
Right middle lobe | 70 (12.0%) | |
Types of multiple cancers (according to 8th TNM stage) | ||
Multifocal GG/L nodules | 139 (53.9%) | |
Second primary lung cancer | 63 (24.4%) | |
Multifocal lung cancers with relationship not sure | 47 (18.2%) | |
Separate tumor nodule | 9 (3.5%) | |
With lung nodules not resected* | ||
Yes | 42 (16.3%) | |
No | 216 (83.7%) | |
TNM stage | ||
I | 151 (58.5%) | |
II | 23 (89.1%) | |
III | 37 (14.3%) | |
Not sure | 47 (18.2%) | |