Fig. 6From: METTL14-mediated N6-methyladenosine modification induces the ferroptosis of hypoxia/reoxygenation-induced cardiomyocytesRole and mechanism of METTL14 in regulating H/R-induced ferroptosis in cardiomyocytes. METTL14 induces the recognition and processing of pri-miR-146a-5p by DGCR8 by up-regulating the m6A methylation level on pri-miR-146a-5p, which promotes the expression of miR-146a-5p, which in turn targets and represses the transcriptional level of APPL1 and promotes H/R-induced ferroptosis in cardiomyocytesBack to article page