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Table 1 Characteristics of patients with excessive bleeding vs those withouta

From: Factors associated with excessive bleeding in cardiopulmonary bypass patients: a nested case-control study

Variables < 1000 cc (n = 13) > 1000 cc (n = 13) P
Demographic    
Sex (% males) 6 (46) 9 (69) 0.21
Age (years) 69 (60–75) 64 (61–75) 0.88
Body Mass Index (BMI) (kg/m2) 29.3 (28–32) 26.1 (25–27.9) 0.03
APACHE-II 13 (11–16) 14 (12–18) 0.21
SAPS-II 31 (31–32) 31.5 (29–40) 0.78
Parsonnet 17.5 (13.5–21) 15(9–20.5) 0.55
Surgical parameters    
Type of bypass (%)    0.03
   Venous 4 (31) 0  
   Arterial and venous 8 (61.5) 4 (31)  
Cardiopulmonary bypass time (min) 85 (77–110) 100 (67–110) 0.84
Aortic clamping time (min) 63 (45–71) 55 (50–70) 0.96
Temperature during CPB (°C) 32 (31.5–32) 31 (30–32) 0.04
Laboratory parameters    
C1q 0 h (mg/ml) 10.4(8.7–16.5) 6.9 (6.2–9.1) 0.02
C1q 4 h (mg/ml) 14.9 (9.3–16) 7.6 (7.1–9.8) <0.01
C1q 24 h (mg/ml) 12.8 (9.9–15.6) 8.4 (7.2–10.1) 0.04
C1-Inhibitor 0 h (mg/ml) 20.4 (16.6–21.4) 13.2 (10.4–16.8) 0.03
C1-Inhibitor 4 h (mg/ml) 19.5 (16.2–20.5) 13.2 (10.8–17) 0.04
C4 24 h (mg/ml) 21.2 (17–22.5) 14.7 (13.8–18.8) 0.04
C3 4 h (mg/ml) 87 (76–94) 85(70–88) 0.01
B Factor 0 h (mg/ml) 21.4 (18.9–26.4) 15.6 (15.3–20.2) 0.03
B Factor 4 h (mg/ml) 24.7 (18.7–28.2) 18.6 (17–19.7) 0.02
C7 0 h (mg/ml) 6.3(5.4–8.5) 3.3 (2.5–5.9) <0.01
C7 4 h (mg/ml) 6.6 (5–9.6) 3.3 (2.1–4.6) <0.01
Leptin 0 h (ng/ml) 12.1 (7.5–22.4) 5.5 (1.9–7.7) 0.01
Leptin 4 h (ng/ml) 10.7 (7.8–19.2) 4.2 (1.4–6.2) <0.01
Leptin 24 h (ng/ml) 32.6 (20.4–48.1) 6.9 (3.8–12.3) <0.01
Prothrombin time admission (%) 77 (72–79) 70 (56–71) 0.04
Prothrombin time 4 h (%) 77 (68–81) 67 (64–69) 0.03
Fibrinogen 4 h (mg/ml) 351 (272–409) 272 (209–319) 0.03
Plasminogen activator inhibitor-1 preoperative (ng/ml) 43.5 (31.5–52.8) 25.5 (23–36) 0.01
Plasminogen activator inhibitor-1 0 h (ng/ml) 76.6(53.5–97.3) 35.5 (32.1–42.6) <0.01
PAI-1/t-PA ratio 0 h 3.7 (2.7–6.8) 1.6 (1.2–3.4) 0.014
Hematocrit (%) 4 h 28.6 (25.8–31.9) 25.4 (24–27.8) 0.048
Total red blood cells (ml) 400 (0–800) 1600 (800–2000) <0.01
Total plasma frozen (ml) 0 800 (0–900) 0.047
Blood loss 4 h (mL) 661 (572–992) 220 (170–520) 0.01
Blood loss 24 h (mL) 1190 (978–1762) 605 (470–1100) 0.01
  1. aValues are expressed as median and ranges.