Figure 1

Plasma sFlt1 and sKDR levels during and after cardiopulmonary bypass graft surgery. A: Plasma sFlt-1 values are expressed in pg per mg protein. T0: before vascular cannulation and after opening the chest; T₁: during extracorporeal circulation (ECC); T₂: at the end of ECC before cross clamp release; T₃: after cross clamp release; T4: the 6th post-operative hour; T5: the 24th post-operative hour. Mean ± SEM of 15 patients. *p < 0.001 as compared with T0 (Mann-Whitney U-test). B: Plasma sKDR levels are expressed in pg/mg protein. Same blood sampling time than in A. Mean ± SEM of 15 patients. *p < 0.001 as compared with T0 (Mann-Whitney U-test). No statistical differences were observed (Mann-Whitney U-test). C: Plasma sFlt-1 values at the beginning of ECC. T0: before vascular cannulation and after opening the chest; T_1': before cross clamp; T_2': after cross clamp. Mean ± SEM of 10 patients. *p = 0.0002 as compared with T0 (Mann-Whitney U-test).