Does preservation of the sub-valvular apparatus during mitral valve replacement affect long-term survival and quality of life? A Microsimulation Study

Table 1 Summary of Model Parameters

MODEL PARAMETER	VALUE		RANGE/SD		DISTRIBUTION
Valve-Related Mortality Hazard Ratio 1 Year [5]	0.1084	0.0782	-	0.2049	Triangular
Valve-Related Mortality Hazard Ratio 5 Year [5]	0.0416	0.0197	-	0.0833	Triangular
Overall Survival without Preservation (62 year old cohort) [32]
Year 1	87.4%
Year 2	84.3%
Year 3	81.3%
Year 4	77.5%
Year 5	75.0%
Overall Survival without Preservation (82 year old cohort) [32]
Year 1	79.8%
Year 2	65.9%
Year 3	64.1%
Year 4	58.1%
Year 5	40.7%
Baseline Mortality [31]			GAD Life Tables
Postoperative Utility Without Preservation
Age 60–69	0.6668		0.1410		Normal
Age 70–79	0.6292		0.1330		Normal
Age 80+	0.6058		0.1281		Normal
Postoperative Utility With Preservation
Age 60–69	0.7345		0.0660		Normal
Age 70–79	0.6931		0.0622		Normal
Age 80+	0.6673		0.0599		Normal
Discount Rate [44]	0.0350	0.0000	-	0.0600	Triangular

ISSN: 1749-8090