|
Overall survival, time-dependent treatment effect*
| | |
|
No. of deaths/no. of patients
| | |
|
Treated patients
|
517/5,792
|
95/1,524
|
|
Untreated patients
|
152/541
|
69/363
|
|
Model I, Treatment indicator
| | |
|
Treated vs Untreated
| | |
|
Unadjusted hazard ratio
|
0.53 (0.43–0.65)
|
0.42 (0.30–0.59)
|
|
Adjusted hazard ratio
|
0.54 (0.44–0.66)
|
0.45 (0.32–0.63)
|
|
Model II, Treatment by target time
| | |
|
Early Surgery vs Untreated
| | |
|
Unadjusted hazard ratio
|
0.47 (0.37–0.59)
|
0.35 (0.23–0.55)
|
|
Adjusted hazard ratio
|
0.45 (0.36–0.58)
|
0.36 (0.23–0.56)
|
|
Late Surgery vs Untreated
| | |
|
Unadjusted hazard ratio
|
0.58 (0.47–0.73)
|
0.47 (0.32–0.68)
|
|
Adjusted hazard ratio
|
0.61 (0.49–0.76)
|
0.51 (0.35–0.74)
|
|
Model III, Treatment by target time and admission type
| | |
|
Early Surgery vs Untreated
| | |
|
Unadjusted hazard ratio
|
0.47 (0.37–0.60)
|
0.32 (0.20–0.51)
|
|
Adjusted hazard ratio
|
0.45 (0.36–0.58)
|
0.33 (0.20–0.53)
|
|
Late Surgery vs Untreated
| | |
|
Unadjusted hazard ratio
|
0.58 (0.46–0.73)
|
0.46 (0.32–0.67)
|
|
Adjusted hazard ratio
|
0.61 (0.48–0.76)
|
0.51 (0.35–0.74)
|
|
Unplanned Emergency vs Untreated
| | |
|
Unadjusted hazard ratio
|
0.51 (0.31–0.84)
|
0.80 (0.37–1.76)
|
|
Adjusted hazard ratio
|
0.52 (0.32–0.87)
|
0.73 (0.33–1.63)
|
|
Long-term post-operative survival†
| | |
|
No. of deaths/follow-up yrs
| | |
|
Early Surgery
|
153/8,409
|
31/2,121
|
|
Late Surgery
|
303/13,883
|
64/3,648
|
|
Unadjusted hazard ratio
|
0.85 (0.70–1.03)
|
0.84 (0.55–1.29)
|
|
Adjusted hazard ratio
|
0.79 (0.65–0.96)
|
0.86 (0.55–1.33)
|
