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Table 1 Clinical, radiographic and demographic features of nine patients with suspected cancer recurrence in whom endobronchial ultrasound transbronchial needle aspiration detected granulomatous inflammation.

From: Clinical implications of granulomatous inflammation detected by endobronchial ultrasound transbronchial needle aspiration in patients with suspected cancer recurrence in the mediastinum

Age Sex Race Oncological History Remission (yrs since initial diagnosis) Chemotherapy Lymph node Characteristics Granuloma at other sites Microbiologic Studies* Treatment Follow-up (months)
    Station [8] Size mm PET +ve   Culture (n) Staining Serology   
1
56F
C
Breast Cancer
Neadjuvant
Chemotherapy
Paclitaxel
Lapatinib
7
11R
14
7
- No P N N MAC
Infection
Rifabutin
Ethambutol
Clarithromycin
Radiographical and clinical improvement on antimycobacterial therapy
2
28F
C
Melanoma
(2)
No 4R
7
7
13
- No N (1) N - None No symptoms (11)
3
49M
H
Hodgkin's
Lymphoma
Stage 1a
(8)
No 11R 14 Yes No N (2) N - None No symptoms
Node PET uptake and CT size reduced (6)
4
56F
AA
GI Stromal Tumor
(1)
Imatimib 4R 17 - TBBX** N (1) N - Inhaled
Fluticasone
Productive Cough
Progressive Pulmonary Infiltrates (12)
5
61F
C
NSCLC
T2N2M0
(1)
Carboplatin
Docetaxel
11R 9 Yes No N (1) N - Inhaled
Fluticasone
Chronic cough
Stable CT-PET (6)
6
63M
C
Melanoma
(4)
No 2R
7
10
11
Yes
Yes
Lymphocytic Meningitis** N (3) N N Prednisone
For neurosarcoidosis
Neurological Symptoms
No pulmonary symptoms
Node PET uptake and CT size reduced (15)
7
66M
C
Multiple Myeloma
(3)
Melphalan
Thalidomide
Lenalidomide
11R 11 Yes EBBX**
TBBX
N (2) N N None No symptoms
Stable CT-PET (8)
8
68F
AA
Endometrial Cancer
(2)
Docetaxel
Carboplatin
Imatimib
7
11R
13
10
Yes
Yes
No** N (1) N - None No symptoms
Stable CT-PET
Intraabdominal cancer Recurrence (9)
9
77M
C
Colorectal Cancer
(3)
Cisplatin
Capecitabine
7 10 - No** N (2) N - None No symptoms
Stable CT (10)
  1. * Fungal and mycobacterial cultures (bronchoalveolar lavage or bronchial wash or sputum), tissue staining for fungi and acid fast bacilli (AFB), and serum fungal antibody titers.
  2. ** Pulmonary parenchymal involvement on high resolution CT.
  3. AA = African American, AFB = acid fast bacilli, BAL = bronchoalveolar lavage, C = Caucasian, CT = computed tomography, EBBX = endobronchial biopsy, EBUS = endobronchial ultrasound, F = female, GI = gastrointestinal, H = Hispanic, M = male, MAC = Mycobacterium avium intracellulare infection, N = negative, P = positive, PET = positron emission tomography, TBBX = transbronchial biopsy, Yrs = years