Current role of surgery in small cell lung carcinoma

Table 2 Ongoing trials

Trial	Protocol of treatment
Essen Thoracic Oncology Group	CT × 3 → concurrent CT + Hf-RTx (45 Gy; twice daily) → Surgery → CTRx
West Japan Thoracic Oncology group	Group I: CT × 3 → concurrent CT + Hf-RTx (45 Gy; twice daily) ± PCI → Surgery
	Group II: concurrent CT + Hf-RTx (45 Gy; twice daily) + CT × 2 ± PCI
German Multicenter Randomised Trial	Group I: CT × 5 → Surgery ± RTx (50 Gy; once daily) + PCI
	Group II: CT × 5 + RTx (50 Gy; once daily) + PCI

Ongoing trials of surgery in a multimodality treatment in SCLC. Adapted by Eberhardt and Korfee (13)
CT: chemotherapy, Hf-RTx: hyperfractionated radiotherapy, RTx: radiotherapy, CTRx: chemoradiotherapy, PCI: prophylactic cranial irradiation
Platinum-etoposside based chemotherapy in all 3 trials.
West Japan Thoracic Oncology Trial: PCI given only in complete remission after induction chemoradiotherapy.

ISSN: 1749-8090