The challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study

Table 1 Patient characteristics and results.

Patient	1	2	3	4	5*	6	7	8*	9	10*
Gender	M	M	M	M	M	M	F	F	M	M
Age [years]	64	55	61	44	55	48	37	63	65	29
BMI	26	26	31	22	26	24	24	29	34	24
Months after HTX	89	67	70	63	79	81	90	69	62	68
Prior rejections	1	2	1	0	0	0	0	0	1	2
CA	NL	CAD	NL	NL	CS	NL	NL	NL	CS	CAD
MSCT	NL	CAD	NL	NL	CS	NL	NL	NL	CS	CAD
Calcium mass	0.06	0.13	0	0	0.81	0	0	0	11.3	NP
Biopsy	1 R	1 R	1 R	0	1 R	1 R	0	1 R	1 R	NP
MRI	DF	DF	DF	NF	NP	SF	NF	NP	DF	NP
EF (%) by CA	>55	<55	>55	>55	>55	>55	>55	>55	>55	>55
EF (%) by MRI	51	43	55	63	NP	60	75	NP	77	NP
EF (%) by TTE	61	48	57	71	61	61	73	62	70	69

M: male; F: female. (*) patient with cardiac pacemaker. BMI: body mass index in kg/m². Calcium mass in mg CaHa. NL: no lesion. Biopsy: classification of rejection (ISHLT). Grade 0 R: no rejection; Grade 1 R: mild rejection; Grade 2 R: moderate rejection and Grade 3 R: severe rejection. Magnetic resonance imaging: NF: no fibrosis; SF: slight fibrosis; DF: diffuse fibrosis. NP: not performed. Coronary angiography/multi-slice computed tomography: CAD: Coronary artery disease; CS: Coronary sclerosis. Ejection fraction EF > 55% was defined as normal.

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