Risk profile and occurrence of cardiac adverse events. Out of the seven investigated gene polymorphisms, six were combined for a risk profile (see text). Patients with the risk profile had significantly more reoperations (0.012) and were more likely to have recurrent symptoms (0.0012). The incidence of interventions (PTCA, stent) were not different among the groups (p = 0.38). However, multivariate Cox regression analysis revealed that only the risk profile had significant impact on the incidence of cardiac adverse events (p = 0.004).