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Table 1 Preoperative baseline characteristics of four patients with MR caused by LS endocarditis

From: Mitral valve surgery for mitral regurgitation caused by Libman-Sacks endocarditis: a report of four cases and a systematic review of the literature

Patient 1 2 3 4
Gender Male Male Female Female
Age (years) 49 56 28 22
SLE/APS SLE SLE APS APS
Years of SLE/APS 1.5 4 1 0.5
Steroids yes yes no no
Valve Lesion MR MR MR MR
NYHA class IV I III I
Echocardiography     
   -MR grade 4+ 4+ 4+ 2+
   -LV function normal normal normal normal
Cardiac Catheterization     
   -Coronary artery disease no no no NA
   -PAP (mmHg) (N: 15-30/3-12 mmHg) 34/6 41/18 32/21 NA
   -PCWP (mmHg) (N: 1-10 mmHg) 10 18 21 NA
   -LVEDP (mmHg) (N: 3-12 mmHg) 10 18 19 NA
   -Cardiac Output (L/min/m2) (N: 2.6-4.2 L/min/m2) 2.74 3.20 4.30 NA
Laboratory tests     
   -Repeated blood cultures neg neg neg neg
   -CRP (mg/l) (N: 0-5 mg/l) 38 60 3 34
   -White blood cell count (×109/l) (N: 4.0-10.0 × 109/l) 4.6 3.8 6.8 8.9
   -Thrombocyte count (×109/l) (N: 150-300 × 109/l) 258 249 105 114
   -Lupus anticoagulant (N: neg) NA NA pos pos
   -Anti-cardiolipin Ab (IgG) (U/ml) (N: <10 U/ml) <10 25 >100 53
   -Anti-cardiolipin Ab (IgM) (U/ml) (N: <10 U/ml) <10 <10 <10 <10
   -Complement C3 (g/l) (N: 0.90-1.80 g/l) 0.39 0.77 1.19 1.57
   -Complement C4 (g/l) (N: 0.10-0.40 g/l) 0.13 0.19 0.31 0.39
   -Anti-Nuclear Antibody (ANA) titer (N: <20) 320 >640 40 40
   -Anti-ds-DNA Ab (Farr-assay) (U/ml) (N: <10 U/ml) 11 154 <3 5
   -Extractable Nuclear Antigens (ENA) (N: neg) NA neg neg neg
  1. Ab, antibodies; APS, anti-phospholipid syndrome; CRP, C-reactive protein; ds-DNA, double stranded DNA; LS, Libman-Sacks; LV(EDP), left ventricular (end-diastolic pressure); MR, mitral regurgitation; N, normal values; NA, not available; NYHA, New-York heart association; PAP, pulmonary artery pressure; PCPW, pulmonary capillary wedge pressure; SLE, systemic lupus erythematosus
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