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Table 5 Univariate and multivariate Cox regression analyses of risk factors for late mortality†.

From: Preoperative ejection fraction as a predictor of survival after coronary artery bypass grafting: comparison with a matched general population

Risk factor

HR late mortality

Univariate analysis

P value

HR late mortality

Multivariate analysis

P value

EF 35% -50%

1.866 (1.614 -2.157)

< .0001

1.562 (1.339 -1.822)

< .0001

EF < 35%

2.859 (2.231-3.665)

< .0001

1.051 (0.924 -1.196)

< .0001

Age (y)*

1.094 (1.086 -1.103)

< .0001

1.067 (1.053 -1.081)

< .0001

Male sex

0.835 (0.726 -0.961)

.012

1.629 (1.346 -1.97)

< .0001

NYHA class

1.201 (1.094 -1.318)

< .0001

1.501 (1.267 -1.779)

< .0001

Angina class

1.002 (0.951-1.055)

.95

  

Hypertension

1.223 (1.079 -1386)

.002

1.137 (0.971 -1.33)

.11

COPD

1.778 (1.523 -2.077)

< .0001

1.473 (1.211 -1.792)

< .0001

Diabetes

1.733 (1.512 -1.985)

< .0001

1.526 (1.287 -1.809)

< .0001

Preoperative CrCl

0.965 (0962 -0.968)

< .0001

0.986 (0.981 -0.992)

< .0001

PVD

2.307 (1.978 -2.690)

< .0001

1.699 (1.397 -2.066)

< .0001

Preoperative Hb

0.743 (0.711 -0.777)

< .0001

0.867 (0.816 -0.922)

< .0001

Prior cardiac surgery

1.536 (1.248 -1.891)

< .0001

1.143 (0.851-1.536)

.374

Emergency

1.268 (0.957 -1.681)

.099

  

No. of anastomoses

1.089 (1.032 -1.148)

.002

  

Use of IMA

0.544 (0.465 -0.637)

< .0001

  

Off-pump

0.76 (0.58 -0.996)

.046

  

Perioperative MI

1.801 (1.331-2.437)

< .0001

  

Re-exploration

1.673 (1.344 -2.082)

< .0001

  

IABP

1.903 (1.364 -2.655)

< .0001

  
  1. HR = Hazard ratio, EF = ejection fraction, NYHA = New York Heart Association, COPD = chronic obstructive pulmonary disease, CrCl = creatinine clearance, PVD = peripheral vascular disease, Hb = hemoglobin, IMA = internal mammary artery, MI = myocardial infarction, IABP = intra-aortic balloon pump support.
  2. † Only preoperative variables which are significant in the univariate analysis were entered into the multivariate analysis
  3. *Entered as a continuous variable.