Initial experience with a synthetic sealant PleuraSeal™ after pulmonary resections: a prospective study with retrospective case matched controls

Table 1 Baseline characteristics and pre-operative variables

Variable^a	Overall	PleuraSeal™ Group	Control Group	p-value^b
	40	20	20
Age (yrs.), mean (SD)		69 (45-82)	66 (47-81)	0.34
Gender
Male	31 (77%)	14 (70%)	17 (85%)
Female	9 (22%)	6 (30%)	3 (15%)	0.45
Chronic lung disease	22	11	11
COPD	19 (47%)	9 (45%)	10 (50%)
Lung emphysema	2 (5%)	2 (10%)	0 (0%)
Asthma	1 (2%)	0 (0%)	1 (5%)	0.58
Pulmonary function ^c
FEV1 actual (Ø %), mean (SD)	85.5 (17.9)	87 (20.2)	84 (15.6)	0.51
FEV1 predicted (Ø %), mean (SD)	65.5 (16.2)	69 (17.6)	62 (14.8)	0.18
DLCO actual (Ø %), mean (SD)	70.5 (14.5)	70 (15.7)	71 (13.3)	0.84
DLCO predicted (Ø %), mean (SD)	55 (14.6)	56 (16.3)	54 (12.9)	0.55
Neoadjuvant therapy	1	0	1
Radiation	0 (0%)	-	-	NA
Chemotherapy	1 (2%)	0 (0%)	1 (5%)	1.00
Concomitant disease	23	14	9
Diabetes	7 (17%)	4 (20%)	3 (15%)	1.00
Others^d	16 (40%)	10 (50%)	6 (30%)	0.23
Smoking behaviour
Current Smoker	15 (37%)	8 (40%)	7 (35%)
Ex smoker (≥12 month)	13 (32%)	6 (30%)	7 (35%)
Never smoked	12 (30%)	6 (30%)	6 (30%)	0.14

^aNumbers in percentage were rounded up were indicated.
^bContinuous variables were compared between groups by Students' t-test. Categorical variables were compared using two-sided Fisher's Exact test..
^cPreoperative pulmonary function test and postoperative variables based on amount of lung resection; FEV1: Forced expiratory volume (1 sec); DLCO: CO volume-adjusted diffusion capacity). Data shown in % of total function and as mean with SD where indicated; SD standard deviation.
^dOther entities: hypertension, cardiac insufficiency, arrhythmia absoluta

ISSN: 1749-8090