Table 1 Demographical, clinical and operative data of the patients (n = 40)
Characteristics | Atorvastatin pretreatment n = 20 | No atorvastatin pretreatment n = 20 | P for difference |
|---|---|---|---|
Demographical and baseline clinical data | |||
Age, y | 58.8 (8)* | 61 (11) * | 0.44 |
Weight, kg (mean ± SD) | 83.1 ± 2.4 | 83.6 ± 2.3 | 0.88 |
Male to female ratio | 16/4 | 15/5 | 1.0 |
Diabetes, n (%) | 7 (35%) | 9 (45%) | 0.51 |
Hypertension, n (%) | 6 (30%) | 6 (30%) | 1.0 |
Ejection fraction, % | 40 (8.5)* | 40 (13.5)* | 0.26 |
LDL, mg/dl (mean ± SD) | 100.7 ± 9.20 | 97.5 ± 6.0 | 0.20 |
CK-MB, ng/ml | 2 (1.5)* | 1.85 (1.6)* | 0.79 |
Troponin I, ng/ml | 0.2 (0.2)* | 0.2 (2.6)* | 0.30 |
Erythrocyte sedimentation rate, mm/h (mean ± SD) | 18.9 ± 7.3 | 18.3 ± 6.8 | 0.77 |
Preoperative creatinine level, mg/dl | 1.0 (0.3)* | 1.0 (0.28)* | 0.47 |
Intraoperative and postoperative parameters | |||
Duration of aortic cross clamp, min (mean ± SD) | 63.5 ± 20.8 | 65.3 ± 20.9 | 0.79 |
Duration of CPB, min (mean ± SD) | 103.2 ± 30.7 | 98.3 ± 26.3 | 0.58 |
ICU stay time, d | 2.0 (1.0)* | 3.5 (2.5)* | 0.046 |
Duration of intubation, h | 8.0 (5.5)* | 7.0 (10.25)* | 0.968 |
PO2, mmHg | 93.8 (22.93)* | 86.0 (20.99)* | 0.26 |
CO2, mmHg | 36.45 (3.64)* | 37.8 (3.67)* | 0.25 |
SaO2, % | 97.0 (3.75)* | 95.4 (3.25)* | 0.686 |
Inotropic support, n (%) | 10 (50%) | 13 (65%) | 0.33 |
Duration of hospitalization, d | 7.0 (1.0)* | 8.0 (1.75)* | 0.25 |
Number of bypasses, n | 3.0 (1.75)* | 3.0 (1.0)* | 0.14 |
Postoperative creatinine level, mg/dl | 1.1 (0.48)* | 0.95(0.6)* | 0.37 |
Need for blood and blood products, U | 3.5 (1.0)* | 4.0 (1.0)* | 0.97 |
Postoperative EF, % | 40 (10.25)* | 42 (10.25)* | 0.94 |
Total postoperative bleeding, ml | 762.5 (298.7)* | 775 (267.5)* | 0.82 |