From: Thrombotic gene polymorphisms and postoperative outcome after coronary artery bypass graft surgery
Study population (n = 220) | FVL 1691 G/G (n = 196) | FVL 1691 G/A (n = 24) | p value* | PT 20210 G/G (n = 212) | PT 20210 G/A (n = 8) | p value** | ACE I/I and ACE I/D (n = 124) | ACE D/D+ (n = 57) | p value*** | |
---|---|---|---|---|---|---|---|---|---|---|
Age (yrs), mean ± SD | 62.5 ± 10.2 | 62.5 ± 10.2 | 62.3 ± 10.6 | NS | 62.7 ± 10.2 | 57.6 ± 8.5 | NS | 62.0 ± 9.7 | 63.2 ± 10.5 | NS |
Female sex, n (%) | 58 (26.4) | 54 (24.6) | 4 (16.7) | NS | 56 (26.4) | 2 (25) | NS | 29 (23.4) | 13 (22.8) | NS |
Body surface area (m2), mean ± SD | 1.8 ± 0.2 | 1.8 ± 0.2 | 1.8 ± 0.1 | NS | 1.8 ± 0.2 | 1.8 ± 0.2 | NS | 1.8 ± 0.2 | 1.79 ± 0.14 | NS |
Hypertension, n (%) | 89 (40.5) | 80 (40.8) | 9 (37.5) | NS | 88 (41.5) | 1 (12.5) | NS | 46 (37.1) | 34 (59.7) | 0.004 |
Diabetes, n (%) | 118 (53.6) | 107 (54.6) | 11 (45.8) | NS | 113 (53.3) | 5 (62.5) | NS | 68 (54.8) | 29 (50.9) | NS |
Hypercholesterolemia, n (%) | 94 (42.7) | 83 (42.4) | 11 (45.8) | NS | 92 (43.4) | 2 (25) | NS | 59 (47.6) | 28 (49.1) | NS |
Smoking, n (%) | 122 (55.5) | 107 (54.6) | 15 (62.5) | NS | 122 (57.6) | 2 (25) | NS | 66 (53.2) | 35 (61.4) | NS |
Previous stroke, n (%) | 3 (1.4) | 3 (1.5) | 0 | NS | 3 (1.4) | 0 | NS | 1 (0.8) | 1 (1.8) | NS |
Peripheral arterial disease, n (%) | 25 (11.4) | 22 (11.2) | 3 (12.5) | NS | 24 (11.3) | 1 (12.5) | NS | 10 (8.1) | 13 (22.8) | 0.006 |
Previous hospital admission for MI, n (%) | 52 (23.6) | 43 (21.9) | 9 (37.5) | NS | 51 (24.1) | 1 (12.5) | NS | 26 (21.0) | 23 (40.4) | 0.007 |
COPD, n (%) | 32 (14.6) | 28 (12.7) | 4 (16.7) | NS | 32 (15.1) | 0 | NS | 17 (13.7) | 12 (21.1) | NS |
Creatinine > 2.3 mg/dL, n (%) | 7 (3.2) | 5 (2.6) | 2 (8.3) | NS | 6 (2.8) | 1 (12.5) | NS | 1 (0.8) | 2 (3.5) | NS |
Catheter lab emergency, n (%) | 5 (2.6) | 5 (2.6) | 0 | NS | 4 (1.9) | 1 (12.5) | NS | 0 | 2 (3.5) | NS |
Number of diseased coronary arteries, n (%) | 2.4 ± 0.7 | 2.4 ± 0.7 | 2.4 ± 0.7 | NS | 2.4 ± 0.7 | 2.4 ± 0.9 | NS | 2.4 ± 0.71 | 2.5 ± 0.7 | NS |
Totally Occluded Coronary Arteries, n (%) | 0.1 ± 0.3 | 0.1 ± 0.2 | 0.46 ± 0.7 | < 0.001 | 0.08 ± 0.3 | 0.3 ± 0.5 | < 0.001 | 0.1 ± 0.35 | 0.1 ± 0.3 | NS |
Left ventricular aneurysm, n (%) | 10 (4.6) | 5 (2.6) | 5 (20.8) | 0.002 | 9 (4.3) | 1 (12.5) | NS | 8 (6.5) | 1 (1.8) | NS |
Intracardiac thrombus, n (%) | 2 (0.9) | 2 (0.9) | 0 | NS | 2 (0.9) | 0 | NS | 1 (0.8) | 1 (1.8) | NS |
Ischemic mitral regurgitation, n (%) | 19 (8.6) | 16 (8.2) | 3 (12.5) | NS | 17 (8.0) | 2 (25) | NS | 15 (12.1) | 4 (7.0) | NS |
LVEF (%) mean ± SD | 52.8 ± 9.9 | 53.3 ± 9.9 | 49.3 ± 9.0 | NS | 52.7 ± 10.0 | 55.9 ± 4.9 | NS | 53.6 ± 10.1 | 52.84 ± 10.1 | NS |
EuroScore, mean ± SD | 1.3 ± 1.3 | 1.9 ± 1.5 | 1.9 ± 1.5 | NS | 2.0 ± 1.5 | 1.9 ± 1.5 | NS | 1.85 ± 1.5 | 1.93 ± 1.4 | NS |