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Table 1 Published Studies with small number of patients nHL: Non Hodgkin Lymphoma MALToma: mucosa-associated lymphoid tissue

From: Forty years literature review of primary lung lymphoma

Author Year Journal Number nHL MALT Comments/Outcome
Gao J[5] 2002 Zhonghua Jie He He Hu Xi Za Zhi 6    Misdiagnosis is common. Persistent cough is the most common symptom
Zhang L[6] 2006 Zhonghua Wai Ke Za Zhi 10 8   3 cases IE, 2 cases II 1E, 2 cases II 2E and 1 case of II 2EW. All patients had Pneumonectomy & ChemoTx. Survival > 17 months. Advanced (stage II 2E) B-cell low grade and Hodgkin disease lead to poor prognosis
Tian XL[7] 2008 Zhonghua Jie He He Hu Xi Za Zhi 18 7 9 CT features: nodules 14/18, Pleural effusion 5/18. Treatment with Surgery & CTx/RTx. Survival > 11 months: 13 pts, with one death and 4 patients lost to follow up
Varona JF[8] 2005 Tumori 6 6   Mono-CTx treatment with alkylating agents. The authors suggest that the outcome is favorable whatever the treatment modalities
Peterson H[9] 1985 Cancer 6 5   Authors suggest that the treatment is surgical resection and that Rtx and CTx are used when residual disease is present after surgery. Median time to death:48,6 months
Muller C[10] 1990 Rev Pneumol Clin 9    Treatment is surgical in localized forms; there is no firmly established treatment in extensive forms
Mu XD[11] 2007 Beijing Da Xue Xue Bao 1   1 MALT with features: consolidation of right middle lobe and left lower lobe, left pleural effusion with monocytes, monoclonal protein in the electrophoresis of serum, CD20 positive
Natali F[12] 1984 Rev Pneumol Clin 2 2   Discussion about PLL related diseases with a varying degree of malignancy: interstitial lymphocytic pneumonitis ILP, pseudolymphoma PL, lymphomatoid granulomatosis LYG
Deng L[13] 2003 Zhonghua Jie He He Hu Xi Za Zhi 3 3   Radiological features of 3 cases and the role of percutaneous biopsy
Nakachi S[14] 2007 Gan To Kagaku Ryoho 2    2 cases of PPHodgkinL
Martinez RC[15] 2004   1 1   PPL presenting as a pulmonary mass with cavitation
Colby TV[16] 1982   20 20?   
Toh HC[17] 1997 Leuk Lymphoma 11 11   Mean age 50. Lower lobe involvement was the commonest. Small lymphocytic lymphoma was the most common. Good symptom control and radiologic response was achieved with chemotherapy
Marchevsky A[18] 1983 Cancer 5    Criteria for pseudolymphoma Vs PLL. 167 Cases in the literature were analyzed
Morisako T[19] 1998 Nihon Kokyuki Gakkai Zasshi 6 6   Southern blot analysis of lung biopsy: rearrangement of a heavy chain gene
Kim JH[20] 2004 Jpn J Clin Oncol 24 9 15 50% of the patients were asymptomatic at presentation. Bronchoscopy: 30% yield, 67% needed surgical procedure for diagnosis. Overall survival at 3 years: 86%
Addis BJ[21] 1988 Histopathology 15    The diagnosis was based in 13 cases: on Light chain restriction
Arinc S[22] 2006 Tuberk Toraks     Review paper on the current approach in PLL
Xu HY[23] 2007 Chin Med J 12   12 Diagnosis and treatment of MALTomas. 2 pts also had gastric MALTS. Operation was performed on 6 patients. 4 pts treated with Chemo alone. Mean survival 71.3 months. One patient experience recurrence 152 months following operation. Several treatment methods can be used to achieve good outcomes
Pagani M[24] 2007 Tumori 1 1   Single case of right hilar LL.
Cao MS[25] 2008 Zhonghua Jie He He Hu Xi Za Zhi 2 cases of NK/T cell L. Also Literature review of 3 cases    Aggressive tumors. Contrary to nHL most patients presents with symptoms.
Pleural effusions 4/5. Ebstein-Barr was positive in 3/5. Those tumors are CD56(+), CD3(+) but CD20(-). Most pts died within 6/12.
Baas AA[26] 1986 Eur J Respir Dis 1 1   Single case of a 49 y old man with multiple ill defined densities in both lungs treated successfully with Chemotherapy
Ziade N[27] 2005 J Med Liban 1 1   Single case of PLL in an elderly patient
Habermann TM[28] 1999 Semin Oncol     Review article with an emphasis to observations in the clinical management and treatment of PLL
Uematsu M[29] 1997 Kyobu Geka 1 1   PLL of Rt middle lobe treated with lobectomy
Tillawi IS[30] 2007 Saudi Med J 2    2 cases of P Hodgkin lymphoma in young patients. CD30 and CD15 positive in RS cells were detected.
Chu HQ[31] 2007 Zhonghua Jie He He Hu Xi Za Zhi 13   13 MALT is more common in middle age males. Variable radiographic features; bilateral disease in more than 50% of the cases
Le Tourneau A[32] 1983 Hamatol Oncol 15 15   Reference to Kiel- Lennert histo pathological classification. Association of PLL of B type and dysimmune disease
Loh KC[33] 1994 Ann Acad Med Singapore 3 3   Interestingly, despite nodal involvement all patients had surgical resections and adjuvant ChTx. All 3 alive at 92, 51 and 12 months
Cordier JF[34] 1984 Rev Mal Respir 4    The article raises the possible hypothesis that pseudolymphoma may be the initial step in a large spectrum ranging from benign to malignant primary lymphoproliferative lung disorders
Watanabe J[35] 1987 Jpn J Med 1 1   The diagnostic value of surface marker analysis in primary B cell lung lymphoma is emphasized
Toishi M[36] 2004 Kyobu Geka 2   2 Report of 2 cases of MALToma treated with Surgery and post op RadioTherapy
Jayet A[37] 1980 Helv Chir Acta 10    This report emphasizes the fact that surgical treatment of PLL has to be "economical" due to the fact that frequent recurrences (sometimes bilateral) could be encountered
Kuroishi S[38] 2003 Nihon Kokyuki Gakkai Zasshi 1   1 A case of a lingular lobe PLL that relapsed with diffuse micronodular pattern 7 years following surgical resection
Sakula A[39] 1979 Postgrad Med J 1 1   A single case report
Hashizume T[40] 1997 Nihon Kyobu Shikkan Gakkai Zasshi 1 1   A single case report of PLL presented with bilateral infiltrative shadows
Gouldesbrough DR[41] 1988 Histopathology 1    A single case of PLL diagnosed by bronchial cytology and immunocytochemistry
Bosanko CM[42] 1991 J Comput Assist Tomogr 1 1   A single case report presented as an asymptomatic chronic lobar consolidation
Chee YC[43] 1986 Ann Acad Med Singapore 1    Report of a Pseudolymphoma case with a biclonal gammopathy
Bolton- Maggs PH[44] 1993 Thorax 2   2 Report of 2 cases of MALTomas, giving emphasis on the varied clinical and radiological features
Xu TR[45] 1987 Zhonghua Jie He He Hu Xi Za Zhi 2   2 Report of 2 cases of MALTomas, giving emphasis on the varied clinical and pathological features
Konig G[46] 1986 Prax Klin Pneumol 1    The role of BAL in diagnosis of PLL
Ehrenstein F[47] 1966 J. Thorac Cardiovasc Surg 2   2 2 cases of PLL
Tamura A[48] 1995 Jpn J Clin Oncol 24 24   PLL: relationship between clinical features and pathologic findings Pulmonary LL were divided into 4 groups Bcell tumors composed of small to medium size lymphoid cells have the best prognosis
Sakuraba M[49] 2000 Nihon Kokyuki Gakkai Zasshi 3   2 Report of 3 cases
Abe Y[50] 1998 Nihon Kokyuki Gakkai Zasshi 1   1 One case of MALToma diagnosed with flow cytometer analysis, monoclonal gammopathy and Southern blot analysis of the heavy chain of the immunoglobulin gene
Umino T[51] 1993 Nihon Kokyuki Gakkai Zasshi 1 1   A case of PLL diagnosed with: High serum IgG, BAL showing 45% plasma cells and 18% lympocytes, CD19(+), IgG/albumin ratio 13 times higher and IL-6/albumin ratio29 times higher in BAL than serum. The PCR on the DNA extracted from the surgical specimen showed rearrangement of the immunoglobulin heavy chain gene
Zinzani PL [52] 2003   12    MALTomas
Herbert A[53] 1984 Hum Pathol 9 9   The authors claim that histologic evidence of lymph node involvement is unusual even in the presence of mediastinal or pleural infiltration
Davis WB[54] 1987 Chest 1 1   Report of one case of bilateral interstitial infiltrates with lymhocytic alveolitis on the BAL
Pisani RJ[55] 1990 Mayo Clin Proc 1 1   Report of the first case wherein PLL was diagnosed with immunohistologic (less diagnostic for T cell lymphomas) and molecular biologic studies of BAL.
Sprague RI[56] 1989 Chest 1    A case of an elderly female with multiple densities on CXR. Diagnosis was made with transthoracic fine needle aspiration
Julsrud PR[57] 1978 Radiology     Pseudolymphoma & lymphocytic interstitial pneumonitis have a different radiographic pattern to lymphocytic lymphoma
Lewis ER[58] 1991 AJR Am J Roentgenol 31    CT findings of pulmonary lymphoma: masslike consolidation (68%), multiple nodules (55%). 2/3 of the patients have more than one type of CT finding simultaneously
Bellotti M[59] 1987 Respiration 5    Report a series of 5 PLL out of 9 lymphomas involving the lung
Kilgore TL[60] 1983 Chest 4    4 cases of endobronchial nHL. The authors claim that all the patients had disseminated disease at the time of endobronchial involvement.
Rose RM[61] 1986 Cancer 3    3 cases of endobronchial nHL. The authors have identified 2 patterns of endobronchial involvement: Type 1 characterized by submucosal infiltrates occurring in the presence of disseminated disease and Type 2 whereby the central airway is involved by a solitary mass in the absence of disease elsewhere.
Oka M[62] 1988 Am Rev Respir Dis 1    A case report, whereby the diagnosis of PLL was made 5 years after initial presentation
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