Table 1 Published Studies with small number of patients nHL: Non Hodgkin Lymphoma MALToma: mucosa-associated lymphoid tissue

Gao J[5]

2002

Zhonghua Jie He He Hu Xi Za Zhi

6

Misdiagnosis is common. Persistent cough is the most common symptom

Zhang L[6]

2006

Zhonghua Wai Ke Za Zhi

10

8

3 cases IE, 2 cases II 1E, 2 cases II 2E and 1 case of II 2EW. All patients had Pneumonectomy & ChemoTx. Survival > 17 months. Advanced (stage II 2E) B-cell low grade and Hodgkin disease lead to poor prognosis

Tian XL[7]

2008

Zhonghua Jie He He Hu Xi Za Zhi

18

7

9

CT features: nodules 14/18, Pleural effusion 5/18. Treatment with Surgery & CTx/RTx. Survival > 11 months: 13 pts, with one death and 4 patients lost to follow up

Varona JF[8]

2005

Tumori

6

6

Mono-CTx treatment with alkylating agents. The authors suggest that the outcome is favorable whatever the treatment modalities

Peterson H[9]

1985

Cancer

6

5

Authors suggest that the treatment is surgical resection and that Rtx and CTx are used when residual disease is present after surgery. Median time to death:48,6 months

Muller C[10]

1990

Rev Pneumol Clin

9

Treatment is surgical in localized forms; there is no firmly established treatment in extensive forms

Mu XD[11]

2007

Beijing Da Xue Xue Bao

1

1

MALT with features: consolidation of right middle lobe and left lower lobe, left pleural effusion with monocytes, monoclonal protein in the electrophoresis of serum, CD20 positive

Natali F[12]

1984

Rev Pneumol Clin

2

2

Discussion about PLL related diseases with a varying degree of malignancy: interstitial lymphocytic pneumonitis ILP, pseudolymphoma PL, lymphomatoid granulomatosis LYG

Deng L[13]

2003

Zhonghua Jie He He Hu Xi Za Zhi

3

3

Radiological features of 3 cases and the role of percutaneous biopsy

Nakachi S[14]

2007

Gan To Kagaku Ryoho

2

2 cases of PPHodgkinL

Martinez RC[15]

2004

1

1

PPL presenting as a pulmonary mass with cavitation

Colby TV[16]

1982

20

20?

Toh HC[17]

1997

Leuk Lymphoma

11

11

Mean age 50. Lower lobe involvement was the commonest. Small lymphocytic lymphoma was the most common. Good symptom control and radiologic response was achieved with chemotherapy

Marchevsky A[18]

1983

Cancer

5

Criteria for pseudolymphoma Vs PLL. 167 Cases in the literature were analyzed

Morisako T[19]

1998

Nihon Kokyuki Gakkai Zasshi

6

6

Southern blot analysis of lung biopsy: rearrangement of a heavy chain gene

Kim JH[20]

2004

Jpn J Clin Oncol

24

9

15

50% of the patients were asymptomatic at presentation. Bronchoscopy: 30% yield, 67% needed surgical procedure for diagnosis. Overall survival at 3 years: 86%

Addis BJ[21]

1988

Histopathology

15

The diagnosis was based in 13 cases: on Light chain restriction

Arinc S[22]

2006

Tuberk Toraks

Review paper on the current approach in PLL

Xu HY[23]

2007

Chin Med J

12

12

Diagnosis and treatment of MALTomas. 2 pts also had gastric MALTS. Operation was performed on 6 patients. 4 pts treated with Chemo alone. Mean survival 71.3 months. One patient experience recurrence 152 months following operation. Several treatment methods can be used to achieve good outcomes

Pagani M[24]

2007

Tumori

1

1

Single case of right hilar LL.

Cao MS[25]

2008

Zhonghua Jie He He Hu Xi Za Zhi

2 cases of NK/T cell L. Also Literature review of 3 cases

Aggressive tumors. Contrary to nHL most patients presents with symptoms.

Pleural effusions 4/5. Ebstein-Barr was positive in 3/5. Those tumors are CD56(+), CD3(+) but CD20(-). Most pts died within 6/12.

Baas AA[26]

1986

Eur J Respir Dis

1

1

Single case of a 49 y old man with multiple ill defined densities in both lungs treated successfully with Chemotherapy

Ziade N[27]

2005

J Med Liban

1

1

Single case of PLL in an elderly patient

Habermann TM[28]

1999

Semin Oncol

Review article with an emphasis to observations in the clinical management and treatment of PLL

Uematsu M[29]

1997

Kyobu Geka

1

1

PLL of Rt middle lobe treated with lobectomy

Tillawi IS[30]

2007

Saudi Med J

2

2 cases of P Hodgkin lymphoma in young patients. CD30 and CD15 positive in RS cells were detected.

Chu HQ[31]

2007

Zhonghua Jie He He Hu Xi Za Zhi

13

13

MALT is more common in middle age males. Variable radiographic features; bilateral disease in more than 50% of the cases

Le Tourneau A[32]

1983

Hamatol Oncol

15

15

Reference to Kiel- Lennert histo pathological classification. Association of PLL of B type and dysimmune disease

Loh KC[33]

1994

Ann Acad Med Singapore

3

3

Interestingly, despite nodal involvement all patients had surgical resections and adjuvant ChTx. All 3 alive at 92, 51 and 12 months

Cordier JF[34]

1984

Rev Mal Respir

4

The article raises the possible hypothesis that pseudolymphoma may be the initial step in a large spectrum ranging from benign to malignant primary lymphoproliferative lung disorders

Watanabe J[35]

1987

Jpn J Med

1

1

The diagnostic value of surface marker analysis in primary B cell lung lymphoma is emphasized

Toishi M[36]

2004

Kyobu Geka

2

2

Report of 2 cases of MALToma treated with Surgery and post op RadioTherapy

Jayet A[37]

1980

Helv Chir Acta

10

This report emphasizes the fact that surgical treatment of PLL has to be "economical" due to the fact that frequent recurrences (sometimes bilateral) could be encountered

Kuroishi S[38]

2003

Nihon Kokyuki Gakkai Zasshi

1

1

A case of a lingular lobe PLL that relapsed with diffuse micronodular pattern 7 years following surgical resection

Sakula A[39]

1979

Postgrad Med J

1

1

A single case report

Hashizume T[40]

1997

Nihon Kyobu Shikkan Gakkai Zasshi

1

1

A single case report of PLL presented with bilateral infiltrative shadows

Gouldesbrough DR[41]

1988

Histopathology

1

A single case of PLL diagnosed by bronchial cytology and immunocytochemistry

Bosanko CM[42]

1991

J Comput Assist Tomogr

1

1

A single case report presented as an asymptomatic chronic lobar consolidation

Chee YC[43]

1986

Ann Acad Med Singapore

1

Report of a Pseudolymphoma case with a biclonal gammopathy

Bolton- Maggs PH[44]

1993

Thorax

2

2

Report of 2 cases of MALTomas, giving emphasis on the varied clinical and radiological features

Xu TR[45]

1987

Zhonghua Jie He He Hu Xi Za Zhi

2

2

Report of 2 cases of MALTomas, giving emphasis on the varied clinical and pathological features

Konig G[46]

1986

Prax Klin Pneumol

1

The role of BAL in diagnosis of PLL

Ehrenstein F[47]

1966

J. Thorac Cardiovasc Surg

2

2

2 cases of PLL

Tamura A[48]

1995

Jpn J Clin Oncol

24

24

PLL: relationship between clinical features and pathologic findings Pulmonary LL were divided into 4 groups Bcell tumors composed of small to medium size lymphoid cells have the best prognosis

Sakuraba M[49]

2000

Nihon Kokyuki Gakkai Zasshi

3

2

Report of 3 cases

Abe Y[50]

1998

Nihon Kokyuki Gakkai Zasshi

1

1

One case of MALToma diagnosed with flow cytometer analysis, monoclonal gammopathy and Southern blot analysis of the heavy chain of the immunoglobulin gene

Umino T[51]

1993

Nihon Kokyuki Gakkai Zasshi

1

1

A case of PLL diagnosed with: High serum IgG, BAL showing 45% plasma cells and 18% lympocytes, CD19(+), IgG/albumin ratio 13 times higher and IL-6/albumin ratio29 times higher in BAL than serum. The PCR on the DNA extracted from the surgical specimen showed rearrangement of the immunoglobulin heavy chain gene

Zinzani PL [52]

2003

12

MALTomas

Herbert A[53]

1984

Hum Pathol

9

9

The authors claim that histologic evidence of lymph node involvement is unusual even in the presence of mediastinal or pleural infiltration

Davis WB[54]

1987

Chest

1

1

Report of one case of bilateral interstitial infiltrates with lymhocytic alveolitis on the BAL

Pisani RJ[55]

1990

Mayo Clin Proc

1

1

Report of the first case wherein PLL was diagnosed with immunohistologic (less diagnostic for T cell lymphomas) and molecular biologic studies of BAL.

Sprague RI[56]

1989

Chest

1

A case of an elderly female with multiple densities on CXR. Diagnosis was made with transthoracic fine needle aspiration

Julsrud PR[57]

1978

Radiology

Pseudolymphoma & lymphocytic interstitial pneumonitis have a different radiographic pattern to lymphocytic lymphoma

Lewis ER[58]

1991

AJR Am J Roentgenol

31

CT findings of pulmonary lymphoma: masslike consolidation (68%), multiple nodules (55%). 2/3 of the patients have more than one type of CT finding simultaneously

Bellotti M[59]

1987

Respiration

5

Report a series of 5 PLL out of 9 lymphomas involving the lung

Kilgore TL[60]

1983

Chest

4

4 cases of endobronchial nHL. The authors claim that all the patients had disseminated disease at the time of endobronchial involvement.

Rose RM[61]

1986

Cancer

3

3 cases of endobronchial nHL. The authors have identified 2 patterns of endobronchial involvement: Type 1 characterized by submucosal infiltrates occurring in the presence of disseminated disease and Type 2 whereby the central airway is involved by a solitary mass in the absence of disease elsewhere.

Oka M[62]

1988

Am Rev Respir Dis

1

A case report, whereby the diagnosis of PLL was made 5 years after initial presentation