Table 2 Published Studies with large number of patients
From: Forty years literature review of primary lung lymphoma
Author | Year | Journal | Number of Patients | Characteristics | Appearance | Recurrence | Survival |
|---|---|---|---|---|---|---|---|
Koss MN[63] | 1983 | Hum Pathol | 161 14% pseudolymphomas | 138 nHL. Elderly, mainly asymptomatic | Most cases: Solitary nodule or infiltrate | Most recurrences occur within 3 years | 18 out of 101 patients died from tumor. Pleural effusion was a predictor of mortality |
Turner RR[64] | 1984 | Cancer | 47 | 28 cases of PLL | Â | Â | Good prognosis: 1 patient died in 4 years follow up |
L Hoste R[65] | 1984 | Cancer | 36 nHL | Mean age 53 y. More than 80% of patients >40 y | Single lesions 20 cases. Multiple: 16. Unilateral 26, bilateral 10. IE:24, II1E:2, II2E:8, II2EW:2 58% LPI | 33% of LPI recur. 50% of non LPI recur. Average time to recurrence:69 months | 33% died, most non LPI. No survival difference among cases grouped according to stage(IE Vs II2E). For stage IE LPI group did better. 5 years survival 57% |
Kennedy JL[66] | 1985 | Cancer | 64 pts with lymphoid lesions of lung | 12 patients with primary lymphoma | Heterogenous group of patients | Â | Median survival of 117 months if PLL. For Disseminated lymphoma median survival 33 months |
Li G[67] | 1990 | Histopathology | 62 cases. All B cell but 2 cases of T-cell lymphoma | 43 cases of MALT | 32 of the MALTS showed solitary or multiple sharply defined nodules | Recurrences in 46% of the MALTs | Constitutional symptoms and T cell lymphoma showed a bad prognosis. |
Cordier JF[68] | 1993 | Chest | 70 nHL, no mediastinal adenopathy | Mean age 58.4 y, M:F 1:1, majority non smokers. 87% Low grade. majority MALTs. 13% high grade | Localized opacities 87%. Mass -like appearance 24%, Bilateral disease 21%. Monoclonal gammopathy 30%. | Metastasis 7 pts(stomach, bone marrow, spleen, liver) interval between Dx and mets from 10 months to 7 years | 69% underwent surgical resection. Overall survival 93.6% at 5 years for low grade L 26% treated with chemotherapy alone |
Ferraro P[69] | 2000 | Annals of Thorac Surg | 48 nHL | MALTs 73%. Mean age 61.8 years. Symptoms 62.5% of patients, | Mass lesion 60%, Bilateral disease 44%. Mediastinal-hilar lymphadenopathy 31%. Pleural effusions 15%. IE: 37 patients, II2E:7, II2EW:3, Stage III:1 | Local recurrence 50% | Complete surgical resection 40% overall. Incomplete resection in 29 patients (21 patients with bilateral disease) 73% of MALTs had complete resection. Post op Chemo 54%. Five year survival for MALTs 68% and 10 years 53%.. |
Graham B[70] | 2005 | Annals of Thorac Surg | 18 | MALTs 78%. Mean age 66.4 y M:F 1:2 Symptoms 78% of patients, | Nodules or Mass lesions 72%, Bilateral disease 39%. Mediastinal-hilar lymphadenopathy 39%. Pleural effusions 22%. IIE (39%) pts. | Median time to disease recurrence or death: 6 years | 6% died of disease. Five year survival > 80% |
Hu YH[71] | 2009 | Ann Hematol | 22 | MALTs 54% | Nodules or masses 73%. Mediastinal lymphadenopathy MALTs/non-MALTs: 8/80 | Â | Patients who had surgery tended to have better survival. Five year survival MALTs/Non-MALTs 91% over 21%. |