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Table 3 Perioperative patients’ characteristics within first 24 hours

From: Hemodynamic effects of peri-operative statin therapy in on-pump cardiac surgery patients

Variable

Statin

No-Statin

p-value

(n = 276)

(n = 202)

 

Laboratory findings

   

 Creatinine serum max. (mg/dl)

1.9 ± 1.25

2.0 ± 3.8

0.58

 Increased in serum creatinine (%)

72 ± 116

76 ± 193

0.78

 Creatinine clearance min. (ml/min)

57 ± 32

56 ± 31

087

 Decreased creatinine clearance (ml/min)

18 ± 34

20 ± 42

0.72

 Hematocrit min. (%)

27 ± 4

27 ± 4

0.83

 Urea max. (mg/dl)

39 ± 26

42 ± 57

0.44

 Furosemide mean (mg/d)

96 ± 158

79 ± 100

019

 S-CPK (U/L)

973 ± 990

1139 ± 2559

0.37

 S-CPK-MB (U/L)

45 ± 45

50 ± 77

0.42

 Potassium (mmol/L)

4.5 ± 0.5

4.5 ± 0.5

0.48

 Lactate (mmol/L)

1.6 ± 1.4

1.6 ± 1.9

0.64

 Renal replacement therapy during hospital stay (%)

9.1

8.9

0.95

 Leucocytes (103/μl)

15 ± 7

14 ± 8

0.0001

Scores

   

 Rifle Score (1st POD) (n = 285 / 59,6%)

   

  R (risk) n = 60

32

28

0.72

  I (injury) n = 65

39

26

 

  F (failure) n = 160

88

72

 

 APACHE II Score

15 ± 6

15 ± 7

0.66

 SAPS II Score

25 ± 7

25 ± 8

0.61

Inotropes

   

 Epinephrine (mg/d)

9 ± 123

2 ± 8

0.40

 Norepinephrine (mg/d)

2 ± 16

1 ± 6

0.24

 Enoximone (mg/d)

20 ± 114

22 ± 195

0.88

 Dobutamine (mg/d)

9 ± 44

13 ± 69

0.49

Other agents

   

 Nitroglycerine (mg/d)

12 ± 32

9 ± 21

0.40

 Amiodarone (mg/d)

68 ± 286

60 ± 255

0.73

 Cortisone (mg/d)

21 ± 119

66 ± 449

0.11

Operative characteristics

   

 Cross-clamp time (min)

94 ± 36

94 ± 41

0.90

 Cardiopulmonary bypass time (min)

147 ± 60

140 ± 78

0.30

  1. APACHE Acute Physiology and Chronic Health Evaluation II Score, SAPS: Simplified Acute Physiology Score, S-CPK Serum creatinine phosphokinase.