From: Hemodynamic effects of peri-operative statin therapy in on-pump cardiac surgery patients
Variable | Statin | No-Statin | p-value |
---|---|---|---|
(n = 276) | (n = 202) | ||
Laboratory findings | |||
Creatinine serum max. (mg/dl) | 1.9 ± 1.25 | 2.0 ± 3.8 | 0.58 |
Increased in serum creatinine (%) | 72 ± 116 | 76 ± 193 | 0.78 |
Creatinine clearance min. (ml/min) | 57 ± 32 | 56 ± 31 | 087 |
Decreased creatinine clearance (ml/min) | 18 ± 34 | 20 ± 42 | 0.72 |
Hematocrit min. (%) | 27 ± 4 | 27 ± 4 | 0.83 |
Urea max. (mg/dl) | 39 ± 26 | 42 ± 57 | 0.44 |
Furosemide mean (mg/d) | 96 ± 158 | 79 ± 100 | 019 |
S-CPK (U/L) | 973 ± 990 | 1139 ± 2559 | 0.37 |
S-CPK-MB (U/L) | 45 ± 45 | 50 ± 77 | 0.42 |
Potassium (mmol/L) | 4.5 ± 0.5 | 4.5 ± 0.5 | 0.48 |
Lactate (mmol/L) | 1.6 ± 1.4 | 1.6 ± 1.9 | 0.64 |
Renal replacement therapy during hospital stay (%) | 9.1 | 8.9 | 0.95 |
Leucocytes (103/μl) | 15 ± 7 | 14 ± 8 | 0.0001 |
Scores | |||
Rifle Score (1st POD) (n = 285 / 59,6%) | |||
R (risk) n = 60 | 32 | 28 | 0.72 |
I (injury) n = 65 | 39 | 26 | |
F (failure) n = 160 | 88 | 72 | |
APACHE II Score | 15 ± 6 | 15 ± 7 | 0.66 |
SAPS II Score | 25 ± 7 | 25 ± 8 | 0.61 |
Inotropes | |||
Epinephrine (mg/d) | 9 ± 123 | 2 ± 8 | 0.40 |
Norepinephrine (mg/d) | 2 ± 16 | 1 ± 6 | 0.24 |
Enoximone (mg/d) | 20 ± 114 | 22 ± 195 | 0.88 |
Dobutamine (mg/d) | 9 ± 44 | 13 ± 69 | 0.49 |
Other agents | |||
Nitroglycerine (mg/d) | 12 ± 32 | 9 ± 21 | 0.40 |
Amiodarone (mg/d) | 68 ± 286 | 60 ± 255 | 0.73 |
Cortisone (mg/d) | 21 ± 119 | 66 ± 449 | 0.11 |
Operative characteristics | |||
Cross-clamp time (min) | 94 ± 36 | 94 ± 41 | 0.90 |
Cardiopulmonary bypass time (min) | 147 ± 60 | 140 ± 78 | 0.30 |