Sternal reconstruction for unusual chondrosarcoma: innovative technique
© Nosotti et al; licensee BioMed Central Ltd. 2012
Received: 31 October 2011
Accepted: 2 May 2012
Published: 2 May 2012
The authors report a clinical case of a primary sternal chondrosarcoma, presented as a mass in the anterior mediastinum. The patient was treated with subtotal sternectomy and sternal transplantation followed by radiotherapy. Twelve months after surgery, the patient is in good clinical condition, without any sign of tumor relapse and with normal respiratory mechanics.
Primary malignant tumors of the sternum are uncommon and a presentation mimicking thymoma is rare and unreported. The stermal replacement with a cryopreserved allograft sternum is an innovative technique that overcomes the problems related to the prosthetic biocompatibility or to the bone autograft.
KeywordsChondrosarcoma Sternum Transplantation
Primary malignant tumors of the chest wall are uncommon; nevertheless, chondrosarcoma is the most common malignant tumor of the bony thorax and the single most common malignancy of the sternum. The authors report a successful surgery for primary sternal chondrosarcoma, which was treated with subtotal sternectomy and sternal transplantation.
Primary malignant tumors of the sternum are really rare, and account approximately for 0.5% of primary bone tumors. The chondrosarcoma is the most common primary malignant tumor of the sternum. This tumor generally occurs in young adult men; the patient is usually presented with a gradually growing, painful, hard and fixed mass of the sternum. On chest radiograph, chondrosarcoma commonly appears as a lobulated mass originating from the medullary portion of the bone, the margin is not well defined and the destruction of cortex is common. The chondrosarcoma is generally radiolucent but stippled, ring-like or arc-like calcifications are usually present .
To the authors’ knowledge, their case is the first report of a chondrosarcoma originating from the posterior face of the sternum, integrally preserving the cortex and growing in the anterior mediastinum like a thymoma.
Wide excision remains the key for good local control; total sternectomy must be carried out if the sternum is entirely involved, but a subtotal resection, if possible, is recommended in order to partially preserve the chest wall stability . When a portion of soft tissue must be resected, flap or skin grafting procedures can be utilized. Reconstruction of a large defect needs prosthetic material such as prolene mesh, metal implants, methyl-methacrylate bone cement, polyethylene, etcetera . Unfortunately, ideal prosthetic material does not exist; excessive rigidity can erode adjacent structures, rejection or infection may occur and a real integration of the foreign material is quite impossible.
Following the theory of regenerative medicine, we believe bone graft is the best substitute for the resected sternum; the graft could act as a scaffold for new bone formation, mesenchymal cells could migrate into the graft and a differentiation into osteoblastic elements has been demonstrated . In the case of a large graft, as sternal substitution requires, we prefer allografts to autografts in order to avoid pain and functional impairment on the donor site. Moreover, the cryopreserved bone graft is free from any immunogenic capacity.
From a practical point of view, the cryopreserved sternum is easily manipulated and tailored: a perfect fitting of the osteochondral graft into the defect could be achieved in a few minutes. Time consuming is the fixation of the graft by screws and plates, notwithstanding, the final impression is a satisfactory picture of a solid and biocompatible work.
The sternal replacement with a cryopreserved allograft is a new procedure needing validation; our report follows the first by the Padua group , but considering such a technique promising and rare, we stress the opportunity to accumulate the efforts of all surgical centers into an international file.
Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of written consent is avaiable for review by the Editor-in-Chief of this journal.
The authors wish to acknowledge Prof. Maria Martellini, Francesco Caridei and Maria Grazia Vitali for their support.
- Somers J, Faber LP: Chondroma and chondrosarcoma. Semin Thorac Cardiovasc Surg. 1999, 11: 270-277.View ArticlePubMedGoogle Scholar
- Chapelier AR, Missana MC, Couturaud B: Sternal resection and reconstruction for primary malignant tumors. Ann Thorac Surg. 2004, 77: 1001-1006. 10.1016/j.athoracsur.2003.08.053.View ArticlePubMedGoogle Scholar
- Ashford RU, Stanton J, Khan F, Pringle JA, Cannon SR, Briggs TW: Surgical treatment of chondrosarcoma of the sternum. Sarcoma. 2001, 5: 209-213. 10.1080/13577140120099209.View ArticlePubMedPubMed CentralGoogle Scholar
- Granero-Molto F, Weis JA, Longobardi L, Spagnoli A: Role of mesenchymal stem cells in regenerative medicine: application to bone and cartilage repair. Expert Opin Biol Ther. 2008, 8: 255-268. 10.1517/147125184.108.40.206.View ArticlePubMedGoogle Scholar
- Marulli G, Hamad AM, Cogliati E, Breda C, Zuin A, Rea F: Allograft sternochondral replacement after resection of large sternal chondrosarcoma. J Thorac Cardiovasc Surg. 2010, 139: e69-e70. 10.1016/j.jtcvs.2009.01.007.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.