Table 1 Patient characteristics

N

228

104

20

Age (years)

41.6 ± 8.5

53.2 ± 5.2^*

47.8 ± 6.5^*†

< 0.001

Weight (kg)

57.4 ± 6.9

68.7 ± 6.3^*

63.6 ± 5.3^*†

< 0.001

Male

82 (36.0)

36 (34.6)

5 (25.0)

0.238

Drug dosage (mg/day)

3.1 ± 0.8

3.4 ± 0.8^*

3.6 ± 0.9^*

< 0.001

Blood drug conc. (ng/ml)^a

987.1 ± 253.2

1099.4 ± 276.2^*

1175.1 ± 314.3^*

< 0.001