From: Intravenous flurbiprofen for post-thymectomy pain relief in patients with myasthenia gravis
Characteristic | Flurbiprofen | Control (tramadol) | p value* |
---|---|---|---|
n | 110 | 90 | Ā |
Male/female, n (%) | 59 (53.6)/51 (46.4) | 43 (47.8)/47 (52.2) | 0.504 |
Age at surgery, years | 31.1āĀ±ā11.8 | 30.3āĀ±ā13.1 | 0.691 |
Mean disease duration, years | 1.5āĀ±ā0.8 | 1.8āĀ±ā0.9 | 0.401 |
With/without medulla symptoms, n (%) | 17 (15.5)/93 (84.5) | 15 (16.7)/75 (83.3) | 0.816 |
MGFA stage, n (%) | Ā | Ā | 0.954 |
I | 46 (41.8) | 38 (42.2) | Ā |
IIa | 41 (37.3) | 33 (36.7) | Ā |
IIb | 17 (15.5) | 15 (16.7) | Ā |
IIIa | 6 (5.45) | 4 (4.44) | Ā |
Time of operation (min) | 111.8āĀ±ā25.4 | 116.4āĀ±ā24.0 | 0.843 |
Time of chest drainage (d) | 2.7āĀ±ā0.5 | 2.4āĀ±ā0.8 | 0.927 |
Myasthenia crisis | 4 (3.6) | 3 (3.3) | 0.911 |
MGFA stage at 72 h after operation, n (%) | Ā | Ā | 0.931 |
I | 47 (42.7) | 39 (43.3) | Ā |
IIa | 42 (38.2) | 33 (36.7) | Ā |
IIb | 15 (13.6) | 14 (15.6) | Ā |
IIIa | 6 (5.45) | 4 (4.44) | Ā |
Adverse reactions | Ā | Ā | Ā |
Nausea and vomiting | 14 (12.7) | 26 (28.9) | 0.021 |
Headache | 5 (4.5) | 9 (10.0) | 0.162 |
Facial flushing | 3 (2.7) | 4 (4.4) | 0.526 |