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Table 1 Clinicopathological factors of the total study population

From: Prognostic significance of postoperative serum carcinoembryonic antigen levels in patients with completely resected pathological-stage I non-small cell lung cancer

Factors Total NN group HN group HH group p value a
(n = 263) (n = 198) (n = 44) (n = 21)
Age      0.010
  ≤70 y 140 116 16 8  
  >70 y 123 82 28 13  
Gender      0.002
  Male 132 87 30 15  
Female 131 111 14 6  
Smoking history      < 0.001
  ≥5 PY 135 85 33 17  
  <5 PY 128 113 11 4  
ECOG PS      0.28
  0 222 169 38 15  
  1 41 29 6 6  
Serum CYFRA      0.039
  >3.5 ng/mL 12 5 5 2  
  ≤3.5 ng/mL 251 193 39 19  
Location      0.77
  Right 167 124 30 13  
  Left 96 74 14 8  
Surgical procedure      0.98
  Sublobar resection 38 29 6 3  
  Major resection b 225 169 38 18  
Tumor diameter      0.002
  >30 mm 53 30 17 6  
  ≤30 mm 210 168 27 15  
Histology      0.27
  Adeno 213 165 33 15  
  Squamous 46 30 11 5  
  Others 4 3 0 1  
VPI      0.037
Present 50 31 11 8  
Absent 213 167 33 13  
ALI      0.32
  Present 66 49 9 8  
  Absent 197 149 35 13  
Differentiation c      < 0.001
  Well 168 140 19 9  
  Moderate/Poor 91 55 25 11  
  1. PY, Pack-years; ECOG PS, European cooperative oncology group performance status; CYFRA, Cytokeratin 19 fragment; VPI, Visceral pleural invasion; ALI, Angiolymphatic invasion.
  2. aassociation between the NN group and HN group, the chi-square test.
  3. b Major resection refers to lobectomy or pneumonectomy.
  4. c The grade of differentiation was not determined in 4 patients with adenosquamous carcinoma or carcinoids.