Prognostic significance of postoperative serum carcinoembryonic antigen levels in patients with completely resected pathological-stage I non-small cell lung cancer

Table 1 Clinicopathological factors of the total study population

Factors	Total	NN group	HN group	HH group	p value ^a
Factors	(n = 263)	(n = 198)	(n = 44)	(n = 21)	p value ^a
Age					0.010
≤70 y	140	116	16	8
>70 y	123	82	28	13
Gender					0.002
Male	132	87	30	15
Female	131	111	14	6
Smoking history					< 0.001
≥5 PY	135	85	33	17
<5 PY	128	113	11	4
ECOG PS					0.28
0	222	169	38	15
1	41	29	6	6
Serum CYFRA					0.039
>3.5 ng/mL	12	5	5	2
≤3.5 ng/mL	251	193	39	19
Location					0.77
Right	167	124	30	13
Left	96	74	14	8
Surgical procedure					0.98
Sublobar resection	38	29	6	3
Major resection ^b	225	169	38	18
Tumor diameter					0.002
>30 mm	53	30	17	6
≤30 mm	210	168	27	15
Histology					0.27
Adeno	213	165	33	15
Squamous	46	30	11	5
Others	4	3	0	1
VPI					0.037
Present	50	31	11	8
Absent	213	167	33	13
ALI					0.32
Present	66	49	9	8
Absent	197	149	35	13
Differentiation ^c					< 0.001
Well	168	140	19	9
Moderate/Poor	91	55	25	11

PY, Pack-years; ECOG PS, European cooperative oncology group performance status; CYFRA, Cytokeratin 19 fragment; VPI, Visceral pleural invasion; ALI, Angiolymphatic invasion.
^aassociation between the NN group and HN group, the chi-square test.
^b Major resection refers to lobectomy or pneumonectomy.
^c The grade of differentiation was not determined in 4 patients with adenosquamous carcinoma or carcinoids.

ISSN: 1749-8090