TY - JOUR AU - Takano, Tamaki AU - Terasaki, Takamitsu AU - Wada, Yuko AU - Ohashi, Noburou AU - Komatsu, Kazunori AU - Fukui, Daisuke AU - Amano, Jun PY - 2013 DA - 2013/01/16 TI - Early bioprosthetic valve calcification with alfacalcidol supplementation JO - Journal of Cardiothoracic Surgery SP - 11 VL - 8 IS - 1 AB - We report a case of early bioprosthetic valve calcification in a 76 year-old woman who had received supplementation with alfacalcidol, an analogue of vitamin D, for 3 years after her initial valve replacement. She underwent aortic valve replacement at the age of 71 and subsequently complained of shortness of breath. Ultrasonic cardiography revealed severe aortic stenosis and we performed a second aortic valve replacement with a bioprosthesis. Histopathologic and x-ray examination showed calcification on the explanted valve. She had not presented with any known risk for early bioprosthetic calcification, suggesting that vitamin D supplementation may accelerate calcification of bioprosthetic valves. SN - 1749-8090 UR - https://doi.org/10.1186/1749-8090-8-11 DO - 10.1186/1749-8090-8-11 ID - Takano2013 ER -