Figure 5
From: Splenectomy increases the survival time of heart allograft via developing immune tolerance
Histological assessment of transplanted hearts. Representative images of H&E staining (all magnifications: 20x): A, a heart section from a donor rat showing the normal structure of cardiac myofibers; B-D, heart sections collected from HT group at different time point; B, interstitial edema and inflammatory cell infiltration were observed on day 3 after transplantation; C, cardiomyocyte hemorrhage and an increasing number of inflammatory cell infiltrations were found on day 5 after transplantation; D, diffuse inflammatory infiltrate, myocardial cell necrosis, and destruction of myofibers were observed on day 7 after transplantation; E-I, heart sections collected from splenectomy + HT group at different time point; E-F, no pathology changes could be observed on days 3 and 5 after transplantation; G, mild interstitial edema and cellular infiltration was seen in the myocardium on day 7 after transplantation; H, cardiomyocyte interstitial edema and an increasing inflammatory cell infiltration could be observed on day 15 after transplantation; I, myocardial cell necrosis and destruction of myofibers were observed on day 28 after transplantation.