Outcome of mitral valve plasty or replacement: atrial fibrillation an effect modifier

Table 3 Adjusted effect of plasty procedure versus replacement controlling for confounders and level of interaction (effect modification)

Using the Cox’s regression model
Total mortality
Variables	Level	RR with 95% CL	P-value
MPL/MVR	Yes/No	0.43(0.28-0.74)	0.002
3 vessels CHD	Yes/No	2.74(1.59-4.59)	0.0001
Reopration
MPL/MVR	Yes/No	0.32(0.13-0.81)	0.017
AF	Yes/No	0.47(0.15-1.47)	0.198
AF*(MPL/MVR)	Interaction	5.6(1.21-26.6)	0.028
Presence significant CHD	Yes/no	0.47(0.19-1.14)	0.091
Using the Cox’s model stratified by propensity score quintiles
Total mortality
Variables	Level	RR with 95% CL	P-value
MPL/MVR	Yes/no	0.54(0.32-0.90)	0.02
3 V CHD	Yes/no	2.58(1.50-4.43)	0.001
Reoperation
MPL/MVR	Yes/no	0.75(0.32-1.72)	0.502
Sig. CHD	Yes/no	0.46(017–1.21)	0.1190

Interaction between MPL/MVR and AF:
Absence of AF: RR = 0.32 95% (0.13-0.81) p = 0.017.
Presence of AF: RR = 1.82 95% (0.52-6.4) p = 0.344.
As presence of AF is part of the propensity score. Interaction between MREP and AF could not be performed.
Sig. CHD: Presence of significant coronary artery stenosis > 50% in one of the major coronary artery.

ISSN: 1749-8090