Preoperative thrombin generation is predictive for the risk of blood loss after cardiac surgery: a research article

Table 1 Distribution of patient characteristics and perioperative variables according to postoperative blood loss

	All patients	Group 1	Group 2	P-value
	N=29	N=14	N=15	P-value
Age (years)	65 ± 10	67 ± 9	64 ± 11	0.423
Aspirin exp. preop. n (%)	27 (93,1%)	14 (100%)	13 (86,7%)	0.157
Intraoperatively
Tranexam. acid n (%)	14 (48,3%)	9 (64,3%)	5 (33,3%)	0.096
Heparin-total (IU/kg)	336 ± 54	361 ± 66	314 ± 26	0.023
Protamine-total (mg/kg)	3.35 ± 0.52	3.55 ± 0.61	3.17 ± 0.37	0.048
Crystalloids (ml/kg)	16.9 ± 6.5	19.8 ± 6.4	14.2 ± 5.6	0.018
Colloids (ml/kg)	18.6 ± 5.2	17.2 ± 4.8	19.9 ± 5.4	0.167
PRC (units)*	0.0 (0.0-1.0)	0.0 (0.0-1.0)	0.0 (0.0-1.0)	0.591
FFP (units)	0 ± 0	0 ± 0	0 ± 0	1
PLT (units)*	0.0 (0.0-1.0)	0.0 (0.0-1.0)	0.0 (0.0-0.0)	0.301
PRC cell saver (ml/kg)	5.7 ± 2.0	5.0 ± 1.3	6.4 ± 2.3	0.048
Time on bypass (min)	76 ± 20	70 ± 18	81± 22	0.160
Time X-clamp (min)	48 ± 16	45 ± 14	52 ± 18	0.259
Postoperatively
Blood loss 20 h (ml)	922 ± 384	620 ± 160	1205 ± 307	<0.001
PRC (units)*	1.00 (0.0-5.0)	0.0 (0.0-2.0)	2.0 (0.0-2.0)	0.002
FFP (units)*	0.0 (0.0-2.0)	0.0 (0.0-0.0)	0.0 (0.0-2.0)	0.164
PLT (units)*	0.0 (0.0-1.0)	0.0 (0.0-0.0)	0.0 (0.0-1.0)	0.020
Rethoracotomy n (%)	1 (3,4%)	0 (0%)	1 (6,7%)	0.326

Data shown are mean ± SD. Comparison between the groups was done with student t-test; * median and range are presented instead of mean and SD; colloids = infusion volume and priming volume; FFP fresh frozen plasma, PLT platelets, PRC packed red cells.

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