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Table 3 Relapse Free Survival - Multivariate analysis

From: Recurrence risk after Ivor Lewis oesophagectomy for cancer

  Cox Model Competing risks & Fine & Gray   Cox RFS  
  Relapse Free Survival Local recurrence   Distant recurrence   Step 3 : Final analysis  
  HR 95% CI p HR 95% CI p HR 95% CI p HR 95% CI p
Step 1 : Preoperative data    
Weight loss (%)             
- ≤ 10 1    1    1      
- > 10 1.17 0.63; 2.19 0.615 0.81 0.34; 1.94 0.648 1.74 0.72; 4.22 0.218    
Age (years)             
- < 60 1    1    1      
- > 60 1.79 0.99; 3.23 0.051 1.13 0.55; 2.32 0.731 2.4 0.91; 6.34 0.076    
Tumor stenosis             
- No 1    1    1    1   
- Yes 3.36 1.68; 6.72 0.001 3.46 1.38; 8.70 0.008 2.21 0.78; 6.23 0.135 1.12 0.54; 2.39 0.757
Step 2 : Pathological findings    
Tumor localization             
- Oesophagogastric jct 1.16 0.55; 2.45 0.689 1.27 0.51; 3.16 0.61 0.92 0.30; 2.78 0.879    
- Lower/mid third 1    1    1      
Differentiation             
- undiff./poorly 1.03 0.47; 2.28 0.933 0.32 0.07; 1.33 0.116 3.22 1.03; 10.04 0.044    
- moderately/well 1    1    1      
T Stage             
- pT ≤ 2 1    1    1    1   
- pT > 2 2.91 1.16; 7.31 0.023 1.03 0.28; 3.82 0.955 5.86 0.93; 37.15 0.06 2.42 1.22; 4.79 0.011
N Stage             
- pN0 1    1    1    1   
- pN+ 4.67 1.47; 14.77 0.009 6.01 0.84; 43.10 0.074 3.48 0.68; 17.81 0.135 3.69 1.53; 8.96 0.004
Resection             
- R0 1    1    1      
- R1 or R2 0.52 0.24; 1.13 0.098 0.99 0.35; 2.74 0.98 0.4 0.11; 1.48 0.174    
Lymph node ratio             
- ≤ 0.2 1    1    1    1   
- > 0.2 2.71 1.34; 5.51 0.006 1.25 0.46; 3.44 0.659 2.45 0.81; 7.38 0.112 2.57 1.38; 4.76 0.003
Angiolymph. invasion             
- No 1    1    1      
- Yes 1.98 0.96; 4.09 0.066 1.7 0.58; 5.01 0.329 0.95 0.33; 2.75 0.927    
Neural invasion             
- No 1    1    1      
- Yes 1.14 0.55; 2.38 0.729 1.3 0.43; 3.91 0.64 0.77 0.22; 2.67 0.684