From: Recurrence risk after Ivor Lewis oesophagectomy for cancer
Cox Model | Competing risks & Fine & Gray | Cox RFS | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Relapse Free Survival | Local recurrence | Distant recurrence | Step 3 : Final analysis | |||||||||
HR | 95% CI | p | HR | 95% CI | p | HR | 95% CI | p | HR | 95% CI | p | |
Step 1 : Preoperative data | ||||||||||||
Weight loss (%) | ||||||||||||
- ≤ 10 | 1 | 1 | 1 | |||||||||
- > 10 | 1.17 | 0.63; 2.19 | 0.615 | 0.81 | 0.34; 1.94 | 0.648 | 1.74 | 0.72; 4.22 | 0.218 | |||
Age (years) | ||||||||||||
- < 60 | 1 | 1 | 1 | |||||||||
- > 60 | 1.79 | 0.99; 3.23 | 0.051 | 1.13 | 0.55; 2.32 | 0.731 | 2.4 | 0.91; 6.34 | 0.076 | |||
Tumor stenosis | ||||||||||||
- No | 1 | 1 | 1 | 1 | ||||||||
- Yes | 3.36 | 1.68; 6.72 | 0.001 | 3.46 | 1.38; 8.70 | 0.008 | 2.21 | 0.78; 6.23 | 0.135 | 1.12 | 0.54; 2.39 | 0.757 |
Step 2 : Pathological findings | ||||||||||||
Tumor localization | ||||||||||||
- Oesophagogastric jct | 1.16 | 0.55; 2.45 | 0.689 | 1.27 | 0.51; 3.16 | 0.61 | 0.92 | 0.30; 2.78 | 0.879 | |||
- Lower/mid third | 1 | 1 | 1 | |||||||||
Differentiation | ||||||||||||
- undiff./poorly | 1.03 | 0.47; 2.28 | 0.933 | 0.32 | 0.07; 1.33 | 0.116 | 3.22 | 1.03; 10.04 | 0.044 | |||
- moderately/well | 1 | 1 | 1 | |||||||||
T Stage | ||||||||||||
- pT ≤ 2 | 1 | 1 | 1 | 1 | ||||||||
- pT > 2 | 2.91 | 1.16; 7.31 | 0.023 | 1.03 | 0.28; 3.82 | 0.955 | 5.86 | 0.93; 37.15 | 0.06 | 2.42 | 1.22; 4.79 | 0.011 |
N Stage | ||||||||||||
- pN0 | 1 | 1 | 1 | 1 | ||||||||
- pN+ | 4.67 | 1.47; 14.77 | 0.009 | 6.01 | 0.84; 43.10 | 0.074 | 3.48 | 0.68; 17.81 | 0.135 | 3.69 | 1.53; 8.96 | 0.004 |
Resection | ||||||||||||
- R0 | 1 | 1 | 1 | |||||||||
- R1 or R2 | 0.52 | 0.24; 1.13 | 0.098 | 0.99 | 0.35; 2.74 | 0.98 | 0.4 | 0.11; 1.48 | 0.174 | |||
Lymph node ratio | ||||||||||||
- ≤ 0.2 | 1 | 1 | 1 | 1 | ||||||||
- > 0.2 | 2.71 | 1.34; 5.51 | 0.006 | 1.25 | 0.46; 3.44 | 0.659 | 2.45 | 0.81; 7.38 | 0.112 | 2.57 | 1.38; 4.76 | 0.003 |
Angiolymph. invasion | ||||||||||||
- No | 1 | 1 | 1 | |||||||||
- Yes | 1.98 | 0.96; 4.09 | 0.066 | 1.7 | 0.58; 5.01 | 0.329 | 0.95 | 0.33; 2.75 | 0.927 | |||
Neural invasion | ||||||||||||
- No | 1 | 1 | 1 | |||||||||
- Yes | 1.14 | 0.55; 2.38 | 0.729 | 1.3 | 0.43; 3.91 | 0.64 | 0.77 | 0.22; 2.67 | 0.684 |