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Table 4 Univariate and multivariate Cox analysis of late (>30 days) mortality

From: Impact of prosthesis-patient mismatch on early and late mortality after aortic valve replacement

Variable Univariate analysis Multivariate analysis
P HR (95% CI) P HR (95% CI)
Age, years <0.001 1.07 (1.06-1.08) <0.001 1.84 (1.33-2.56)
Sex (female) 0.403 1.07 (0.91-1.26)   
Severely impaired LV function (EF <30%) <0.001 1.93 (1.40-2.67) <0.001 2.24 (1.10-4.56)
Hypertension 0.055 1.17 (0.99-1.37)   
Diabetes Mellitus <0.001 1.80 (1.49-2.17) 0.001 1.41 (1.16-1.71)
Endocarditis 0.118 0.70 (0.45-1.09)   
Body mass index (BMI), kg/m2 0.837 1.00 (0.98-1.02)   
Peripheral vascular disease (PVD) <0.001 2.61 (2.11-3.21) <0.001 1.99 (1.61-2.46)
Renal dysfunction <0.001 2.34 (1.76-3.13) <0.001 1.69 (1.26-2.27)
Chronic obstructive pulmonary disease (COPD) <0.001 1.64 (1.38-1.97) <0.001 1.67 (1.39-1.99)
Cerebrovascular accident (CVA) <0.001 1.88 (1.40-2.53) <0.001 1.71 (1.27-2.31)
Mechanical prosthetic valve <0.001 0.46 (0.39-0.54) 0.126 0.85 (0.70-1.05)
Concomitant coronary artery bypass grafting (CABG) <0.001 1.58 (1.35-1.84) 0.993 0.99 (0.83-1.21)
Cardiopulmonary bypass (CPB) time, min <0.001 1.01 (1.00-1.01) 0.001 1.01 (1.00-1.01)
Aortic cross-clamp time, min <0.001 1.01 (1.00-1.01) 0.385 1.00 (0.99-1.00)
Prosthesis-patient mismatch (PPM) (cut-off ≤0.85 cm2/m2) 0.032 1.26 (1.02-1.55) 0.235 1.14 (0.92-1.42)
Previous cardiac surgery <0.001 1.58 (1.25-2.00) 0.005 1.43 (1.11-.84)
  1. CI = confidence interval; EF = ejection fraction; HR = hazard ratio; LV = left ventricular.