Table 4 Univariate and multivariate Cox analysis of late (>30 days) mortality

Age, years

<0.001

1.07 (1.06-1.08)

<0.001

1.84 (1.33-2.56)

Sex (female)

0.403

1.07 (0.91-1.26)

Severely impaired LV function

(EF <30%)

<0.001

1.93 (1.40-2.67)

<0.001

2.24 (1.10-4.56)

Hypertension

0.055

1.17 (0.99-1.37)

Diabetes Mellitus

<0.001

1.80 (1.49-2.17)

0.001

1.41 (1.16-1.71)

Endocarditis

0.118

0.70 (0.45-1.09)

Body mass index (BMI), kg/m²

0.837

1.00 (0.98-1.02)

Peripheral vascular disease (PVD)

<0.001

2.61 (2.11-3.21)

<0.001

1.99 (1.61-2.46)

Renal dysfunction

<0.001

2.34 (1.76-3.13)

<0.001

1.69 (1.26-2.27)

Chronic obstructive pulmonary disease (COPD)

<0.001

1.64 (1.38-1.97)

<0.001

1.67 (1.39-1.99)

Cerebrovascular accident (CVA)

<0.001

1.88 (1.40-2.53)

<0.001

1.71 (1.27-2.31)

Mechanical prosthetic valve

<0.001

0.46 (0.39-0.54)

0.126

0.85 (0.70-1.05)

Concomitant coronary artery bypass grafting (CABG)

<0.001

1.58 (1.35-1.84)

0.993

0.99 (0.83-1.21)

Cardiopulmonary bypass (CPB) time, min

<0.001

1.01 (1.00-1.01)

0.001

1.01 (1.00-1.01)

Aortic cross-clamp time, min

<0.001

1.01 (1.00-1.01)

0.385

1.00 (0.99-1.00)

Prosthesis-patient mismatch (PPM) (cut-off ≤0.85 cm²/m²)

0.032

1.26 (1.02-1.55)

0.235

1.14 (0.92-1.42)

Previous cardiac surgery

<0.001

1.58 (1.25-2.00)

0.005

1.43 (1.11-.84)