Table 1 Ratio of gene expression in fat from obese and lean Ossabaw pigs
From: Epicardial adipose excision slows the progression of porcine coronary atherosclerosis
Ratio of obese/lean | ||
|---|---|---|
mRNA | Epicardial Fat | Paracardial Fat |
Inflammatory adipokines or proteins associated with inflammation | ||
11β HSD-1 | 16.0# | 1.2 |
CCL19 | 14.0# | 4.4* |
Adiponectin | 6.7*** | 5.0* |
Prostaglandin D2 synthase | 5.3# | 3.0** |
CCL21 | 3.1* | 1.0 |
TLR4 | 1.8 | 2.0** |
IL-6 | 1.7 | 1.8 |
NGF | 1.6 | 1.6 |
IL-8 | 1.6 | 1.4 |
Unc5b | 1.4 | 1.1 |
Netrin-1 | 1.3 | 0.6 |
CCR7 | 1.2 | 0.8 |
TNF | 1.1 | 1.7 |
IL-1β | 0.8 | 0.6 |
Leptin | 0.7 | 1.5 |
Oxidative stress/reactive oxygen species regulation | ||
gp91phox [NADPH oxidase] | 72.0# | 5.4*** |
SOD | 2.0 | 1.5 |
cytochrome C oxidase | 1.5 | 1.5 |
cyclooxygenase 2 | 2.2 | 1.1 |
Angiogenesis and endothelial cell function | ||
VEGFa | 16.0# | 4.3*** |
Angiotensinogen | 5.3# | 1.6 |
VEGFGR1 | 4.3** | 4.3*** |
Endothelin-1 | 2.5 | 1.7 |
eNOS | 1.1 | 1.4 |
adenosine receptor 1 | 0.7 | 0.9 |