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Table 1 HIT characteristics

From: A retrospective evaluation of fondaparinux for confirmed or suspected heparin-induced thrombocytopenia in left-ventricular-assist device patients

Patient

Type of LVAD

Admission Plt (K/uL)

Temporal Plt nadir (K/uL)*

ELISA OD

4-T probability**

Heme-onc consult

SRA***

HITTST

Time of heparin exposure prior to LVAD surgery (days)TT

Time between heparin exposure and HIT Ab + (days)

1

Heartmate II

157

127

0.54

Low

Y

(-)

No

12

19

2

Heartmate II

120

80

0.82

Intermed

N

n/a

No

n/a

0t

3

Heartware

203

99

0.44

Intermed

Y

n/a

DVT

17

21

4

Heartware

217

118

0.64

Low

N

(-)

No

6

10

5

Heartmate II

166

102

0.63

Low

N

n/a

No

n/aTTT

6

6

Heartmate II

218

30

0.45

Intermed

Y

n/a

No

9

8

7

Heartmate II

42

16

0.63

Low

Y

(-)

DVT, PE, stroke

13

1t

8

Heartmate II

526

45

3.15

High

Y

(+)

PE

5

5

  1. *Temporal Plt Nadir = Plt count nearest (within 24 hr) of HIT antibody + .
  2. **4-T probability: High-probability 6–8 points, intermediate probability 4–5 points, low probability ≤ 3 points.
  3. ***SRA is a send out laboratory assay at our institution with a typical turn-around time of 3–5 days.
  4. THITTS = diagnosed thrombosis at the time of HIT antibody + .
  5. TTData unavailable regarding preadmission or outside facility heparin exposure for any patient (eg. cardiac catheterization).
  6. TTTFirst known exposure to heparin was intraoperative.
  7. tPatient developed + HIT antibody on a subsequent admission after initial admission for LVAD surgery.
  8. HIT = heparin-induced thrombocytopenia.
  9. LVAD = left-ventricular-assist device.
  10. Plt = platelet.
  11. OD = optical density.
  12. SRA = serotonin release assay.
  13. HITTS = heparin-induced thrombotic and thrombocytopenic syndrome at time of HIT antibody + .