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Figure 2 | Journal of Cardiothoracic Surgery

Figure 2

From: Multikinase inhibitor sorafenib prevents pressure overload-induced left ventricular hypertrophy in rats by blocking the c-Raf/ERK1/2 signaling pathway

Figure 2

Sorafenib blocks interstitial collagen deposition following aortic banding. A. Interstitial collagen deposition following AB is evidenced by van Gieson’s staining and predominantly localizes to perivascular spaces. Sorafenib prevents interstitial collagen deposition after AB. B. Quantitative measurement of tissue collagen by SirCol assay normalized to total protein content (μg/mg). Sorafenib blocks this component of LVH (p < 0001, ***). All measurements were performed in duplicate.

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Journal of Cardiothoracic Surgery

ISSN: 1749-8090

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