Sorafenib blocks interstitial collagen deposition following aortic banding. A. Interstitial collagen deposition following AB is evidenced by van Gieson’s staining and predominantly localizes to perivascular spaces. Sorafenib prevents interstitial collagen deposition after AB. B. Quantitative measurement of tissue collagen by SirCol assay normalized to total protein content (μg/mg). Sorafenib blocks this component of LVH (p < 0001, ***). All measurements were performed in duplicate.