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Figure 5 | Journal of Cardiothoracic Surgery

Figure 5

From: Multikinase inhibitor sorafenib prevents pressure overload-induced left ventricular hypertrophy in rats by blocking the c-Raf/ERK1/2 signaling pathway

Figure 5

Sorafenib regulates the increased expression of nuclear transcription factors resulting from AB. mRNA of c-myc (A) and c-fos (B) and GATA4 (C) are measured by reverse transcription quantitative polymerase chain reaction (RT-qPCR), and normalized to the reference gene GAPDH. Increased expression of pro-proliferative transcription factors c-myc (A) and c-fos (B) and pro-hypertrophic factor GATA4 (C) in AB as compared to sham-operated animals (p < 0.0001, *** for banding vehicle versus sham vehicle for all three factors) is inhibited by sorafenib (p < 0.0001, *** for banding vehicle versus banding sorafenib for all three factors). All measurements were performed in duplicate.

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