Figure 6From: Multikinase inhibitor sorafenib prevents pressure overload-induced left ventricular hypertrophy in rats by blocking the c-Raf/ERK1/2 signaling pathway Sorafenib abolishes up-regulation of the pro-hypertrophic factor gene atrial natriuretic peptide ANP in banded animals (p < 0001, ***). ANP mRNA is measured by RT-qPCR and normalized to the reference gene GAPDH. All measurements were performed in duplicate.Back to article page