Figure 1

Allograft survival of CBA mice given oral administration or exposed to various odors of Japanese Herbal Medicines and histologic findings in CBA mice. (A) Results in recipients of a C57BL/6 heart that were untreated or given oral administration of TJ-23 and TJ-114 from the day of transplantation until 7 days afterward. MST, median survival time; *P < 0.01 for difference between 2 groups. (B) Results in recipients of a C57BL/6 heart that were exposed to either water vapor alone or to the odors of TJ-23 and TJ-114 from the day of transplantation until allograft rejection. MST, median survival time; #P < 0.05 for difference between two groups. (C) Results in recipients of a C57BL/6 heart that were exposed to the odor of TJ-23, trimethylthiazoline (TMT), or both agents from the day of transplantation until allograft rejection. MST, median survival time; #P < 0.05 and *P < 0.01 for difference between two groups. (D) Results in naïve, olfactory bulb sham-operated and olfactory-dysfunctional CBA recipients of a C57BL/6 heart exposed to the odor of TJ-23 and in olfactory-dysfunctional CBA recipients with no exposure. Mice were treated from the day of transplantation until allograft rejection. MST, median survival time; *P < 0.01 and #P < 0.05 for difference between two groups. (E) Histologic studies of cardiac allografts obtained from mice given olfactory exposure to TJ-23 and untreated mice (hematoxylin and eosin stain; magnification × 40).