Volume of blood loss and number of transfusion units during TAA surgery. Open bars: cases treated with only FFP (n = 24); Closed bars: cases treated with fibrinogen concentrate as well as conventional transfusion (n = 25). RBC, red blood cell; FFP, fresh frozen plasma; PC, platelet concentrate. One unit (U) of RBC contains 130 ml of red blood cells derived from 200 ml of whole blood. Five units of FFP contain 400 ml of whole plasma, while 10 units of PC contain 2–3 × 1011 of platelets. The data are presented as the mean ± SD. *p < 0.05; **p < 0.01 (by unpaired t-test).