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Figure 4 | Journal of Cardiothoracic Surgery

Figure 4

From: Fibroblast phenotypes in different lung diseases

Figure 4

Statistical analysis of the relevant factors. The first row showed the correlation analysis between TGF-β and α-SMA (a), TGF-β and E-cadherin (b), Twist and α-SMA (c) and Twist and E-cadherin (d) were performed in all the 66 lung cancer samples (including CIS, A, AM). Each cycle in the figure represented one lung cancer sample. But some cycles were overlapped because these samples had a same score. α-SMA expression was lower in CIS than in A (P = 0.026), whereas AM showed higher expression than A (P = 0.009) (Figure 4 e). Vimentin expression was negative in N and H but positive in I. In the cancer samples, Vimentin expression was higher in A than in CIS (P = 0.017) and it was higher in AM than in A (P = 0.022) (Figure 4 f). E-cadherin staining intensity was lower in most CIS than in H (P = 0.008), and it was higher in A than in CIS. E-cadherin expression was significantly lower in AM than in A (P < 0.001) (Figure 4 g). TGF-β expression followed a similar pattern than that of α-SMA and vimentin, with positive expression in I, CIS, A, and AM. TGF-β was expressed at higher levels in AM than in A (P < 0.001). No statistical significance was seen between CIS and A (P = 0.392) (Figure 4 h). Twist expression was seen in I, A and AM (Figure 4 i).

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