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Table 2 Comparison of costs for heparin versus argatroban

From: Safety and economic considerations of argatroban use in critically ill patients: a retrospective analysis

 

Heparin

Argatroban

Mean dosage/ICU day

21744 IE

49.6 mg

Costs/ICU day

2.17 EUR

37.60 EUR

Total costs before HIT (mean ICU LOS before HIT suspicion = 7.5 days)

16.40 EUR

283.90 EUR

Costs for HIT diagnostics

 

27.98 EUR (PF4 ELISA)

52.46 EUR (HIPAA)

PRBC transfusion before HIT suspicion

9.9 units

4.4 units

PRBC total costs before HIT (unit costs = 90 EUR)

900.00 EUR

450.00 EUR

Total costs for anticoagulation and transfusions

916.40 EUR

814.34 EUR

ICU LOS

26

6

Total costs of ICU stay (1050EUR/day)

27.000.00 EUR

6.300.00 EUR

  1. An ICU LOS of 7.5 days and increased RBC transfusion with heparin anticoagulation were assumed. For further details see text.