| |
Group T (n = 8)
|
Group L (n = 6)
|
p value intergroup comparison
|
|---|
|
1st exam
|
2nd exam
|
3rd exam
|
4th exam
|
ANOVA p value
|
1st exam
|
2nd exam
|
3rd exam
|
4th exam
|
ANOVA p value
|
1st exam
|
2nd exam
|
3rd exam
|
4th exam
|
|---|
|
Renal ultrasound
|
|
Renal RI
|
0.67 ± 0.05
|
0.77 ± 0.09
|
0.65 ± 0.05
|
0.62 ± 0.04
|
0.0002
|
0.66 ± 0.04
|
0.69 ± 0.01
|
0.71 ± 0.05
|
0.70 ± 0.04
|
0.2008
|
0.816
|
0.049
|
0.043
|
0.002
|
|
p value; vs. 1st exam
|
–
|
0.025
|
0.425
|
0.093
| |
–
|
0.203
|
0.096
|
0.196
| | | | | |
|
p value; vs. 2nd exam
|
–
|
–
|
0.006
|
0.006
| |
–
|
–
|
0.341
|
0.485
| | | | | |
|
Echocardiography
|
|
LVEDD (mm)
|
58.5 ± 19.8
|
55.1 ± 15.4
|
57.2 ± 16.5
|
56.1 ± 17.6
|
0.9823
|
50.3 ± 9.4
|
51.3 ± 10.3
|
51.0 ± 11.7
|
46.5 ± 6.7
|
0.8112
|
0.371
|
0.614
|
0.446
|
0.230
|
|
LVEF (%)
|
45.1 ± 15.2
|
44.9 ± 14.5
|
45.0 ± 14.0
|
47.0 ± 15.3
|
0.9902
|
53.3 ± 8.3
|
52.8 ± 9.5
|
55.8 ± 11.7
|
52.0 ± 0.3
|
0.9150
|
0.249
|
0.266
|
0.151
|
0.494
|
|
IVC diameter (mm)
|
23.1 ± 5.4
|
23.5 ± 3.2
|
21.5 ± 3.6
|
19.8 ± 3.2
|
0.2336
|
23.1 ± 5.4
|
21.5 ± 2.7
|
21.2 ± 3.2
|
18.2 ± 2.6
|
0.1475
|
0.379
|
0.240
|
0.860
|
0.439
|
|
p value; vs. 1st exam
|
–
|
0.798
|
0.318
|
0.021
| |
–
|
0.541
|
0.793
|
0.023
| | | | | |
|
p value; vs. 2nd exam
|
–
|
–
|
0.049
|
0.004
| |
–
|
–
|
0.783
|
0.036
| | | | | |
|
TAPSE (mm)
|
16.4 ± 3.6
|
17.5 ± 3.4
|
19.0 ± 4.1
|
19.7 ± 4.2
|
0.3165
|
19.8 ± 4.4
|
21.8 ± 2.8
|
21.5 ± 3.4
|
21.5 ± 3.8
|
0.7759
|
0.129
|
0.026
|
0.252
|
0.439
|
|
p value; vs. 1st exam
|
–
|
0.380
|
0.041
|
0.015
| |
–
|
0.216
|
0.387
|
0.419
| | | | | |
|
p value; vs. 2nd exam
|
–
|
–
|
0.127
|
0.087
| |
–
|
–
|
0.771
|
0.813
| | | | | |
|
Laboratory examinations
|
|
Hb (g/dL)
|
10.0 ± 1.4
|
9.7 ± 1.4
|
10.0 ± 1.1
|
10.5 ± 1.5
|
0.6340
|
9.3 ± 0.6
|
9.1 ± 0.7
|
9.9 ± 1.2
|
10.4 ± 1.1
|
0.0893
|
0.259
|
0.369
|
0.920
|
0.881
|
|
p value; vs. 1st exam
|
–
|
0.456
|
0.977
|
0.323
| |
–
|
0.567
|
0.267
|
0.130
| | | | | |
|
p value; vs. 2nd exam
|
–
|
–
|
0.383
|
0.052
| |
–
|
–
|
0.283
|
0.110
| | | | | |
|
Na (mEq/L)
|
136.3 ± 3.9
|
134.1 ± 1.5
|
136.4 ± 4.1
|
138.8 ± 3.2
|
0.0745
|
135.3 ± 2.2
|
135.0 ± 3.9
|
134.7 ± 2.3
|
134.7 ± 2.2
|
0.9699
|
0.616
|
0.571
|
0.384
|
0.019
|
|
p value; vs. 1st exam
|
–
|
0.093
|
0.941
|
0.112
| |
–
|
0.876
|
0.543
|
0.328
| | | | | |
|
p value; vs. 2nd exam
|
–
|
–
|
0.170
|
0.005
| |
–
|
–
|
0.797
|
0.830
| | | | | |
|
Cre (mg/dL)
|
1.1 ± 0.6
|
1.3 ± 0.7
|
1.2 ± 0.5
|
1.1 ± 0.4
|
0.8967
|
1.2 ± 0.5
|
1.2 ± 0.5
|
1.3 ± 0.3
|
1.3 ± 0.3
|
0.9180
|
0.841
|
0.914
|
0.584
|
0.271
|
|
p value; vs. 1st exam
|
–
|
0.079
|
0.190
|
0.502
| |
–
|
0.667
|
0.224
|
0.309
| | | | | |
|
p value; vs. 2nd exam
|
–
|
–
|
0.388
|
0.189
| |
–
|
–
|
0.553
|
0.572
| | | | | |
|
TP (g/dL)
|
6.0 ± 0.6
|
6.0 ± 0.5
|
6.0 ± 0.5
|
6.3 ± 0.4
|
0.9909
|
6.1 ± 0.4
|
6.0 ± 0.4
|
6.0 ± 0.5
|
6.1 ± 0.3
|
0.9763
|
0.923
|
0.880
|
0.987
|
0.308
|
|
p value; vs. 1st exam
|
–
|
0.649
|
0.705
|
0.116
| |
–
|
0.363
|
0.259
|
0.765
| | | | | |
|
p value; vs. 2nd exam
|
–
|
–
|
0.756
|
0.042
| |
–
|
–
|
0.862
|
0.275
| | | | | |
|
Alb (g/dL)
|
3.5 ± 0.4
|
3.3 ± 0.3
|
3.6 ± 0.2
|
3.7 ± 0.5
|
0.2227
|
3.4 ± 0.2
|
3.2 ± 0.3
|
3.4 ± 0.2
|
3.5 ± 0.1
|
0.0987
|
0.681
|
0.660
|
0.146
|
0.380
|
|
p value; vs. 1st exam
|
–
|
0.174
|
0.329
|
0.351
| |
–
|
0.056
|
0.998
|
0.555
| | | | | |
|
p value; vs. 2nd exam
|
–
|
–
|
0.026
|
0.059
| |
–
|
–
|
0.071
|
0.073
| | | | | |
|
Duration requiring IV loop diuretics (days)
|
5.6 ± 1.6
|
8.7 ± 3.6
|
0.051
|
- Abbreviations not defined in the text; LVEDD left ventricular end diastolic diameter, LVEF left ventricular ejection fraction, IVC inferior vena cava, TAPSE tricuspid annular plane systolic excursion, Hb hemoglobin, Na sodium, K potassium, Crea creatinine, TP total protein, Alb albumin; Bold pvalues are significant at the 0.05 level.
