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Table 2 Subgroup analysis

From: Platelets activation is associated with elevated plasma mitochondrial DNA during cardiopulmonary bypass

 

MPV/platelet count

Quartile 1

Quartile 2

Quartile 3

Quartile 4

< 0.09

0.09–0.11

0.11–0.13

> 0.13

Number

14

17

22

15

Age (years)

46.5 ± 9.2

47.1 ± 6.0

47.8 ± 8.3

48.4 ± 12.5

Women

9

9

15

8

BMI

23.4 ± 3.5

24.1 ± 2.7

24.5 ± 3.1

23.7 ± 3.8

BSA (m2)

1.7 ± 0.2

1.8 ± 0.3

1.8 ± 0.2

1.8 ± 0.3

Stable angina

3

3

4

2

Unstable angina

4

5

5

4

STEMI

5

5

8

6

NSTEMI

2

4

5

3

Surgical information

 Aortic cross-clamping time (min)

64.3 ± 21.7

63.1 ± 20.6

64.7 ± 22.3

66.3 ± 19.8

 Total CPB time (min)

96.0 ± 26.3

96.4 ± 28.1

96.1 ± 25.9

98.3 ± 30.2

Laboratory data

 serum creatinine (μmol/L)

0.6 ± 0.2

0.6 ± 0.3

0.5 ± 0.3

0.6 ± 0.2

 TC (mg/dL)

203.7 ± 31.6

200.1 ± 39.3

201.4 ± 36.7

207.2 ± 45.3

 HDL (mmol/L)

1.2 ± 0.4

1.2 ± 0.2

1.3 ± 0.3

1.3 ± 0.2

 LDL (mmol/L)

3.1 ± 0.5

2.9 ± 0.4

3.0 ± 0.4

3.0 ± 0.4

 TG (mmol/L)

1.8 ± 0.3

1.7 ± 0.4

1.7 ± 0.2

1.8 ± 0.3

 Glucose (mg/dL)

132.1 ± 31.4

139 ± 30.7

121.5 ± 36.3

145.3 ± 31.1

 RBC (×1012/L)

4.4 ± 0.4

4.2 ± 0.3

4.3 ± 0.3

4.1 ± 0.5

 WBC (×1012/L)

5.6 ± 1.5

4.9 ± 1.7

6.4 ± 1.3

6.0 ± 1.0

 Hemoglobin (g/L)

125.2 ± 11.9

123.8 ± 14.9

130.1 ± 11.3

122.5 ± 10.1

 Hematocrit (%)

38.2 ± 3.7

38.1 ± 3.2

38.4 ± 5.3

37.2 ± 3.9

 MPV/platelet count ratio

0.08 ± 0.009

0.10 ± 0.010

0.12 ± 0.009

0.14 ± 0.011

 Plasma mtDNA (copies/μL)

798 ± 49

889 ± 65*

953 ± 87*

1021 ± 58*

 TNF-α (pg/mL)

164 ± 39

204 ± 42*

294 ± 37*

337 ± 29*

 IL-6 (pg/mL)

181 ± 43

223 ± 38*

298 ± 42*

328 ± 37*

  1. Variables are presented as mean ± SD or as numbers. BMI body mass index, BSA body surface area, STEMI ST-segment myocardial infarction, NSTEMI Non-ST-segment myocardial infarction, CPB cardiopulmonary bypass, TC total cholesterol, HDL high density lipoprotein, LDL low density lipoprotein, TG triglycerides, RBC red blood cell, WBC white blood cell, MPV mean platelet volume, TNF-α tumor necrosis factor-α, IL-6 interleukin-6. *P < 0.05 vs. respective Quartile 1