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Table 1 Summary of baseline, infection, diagnostic, treatment and outcome parameters

From: Daptomycin for the treatment of major gram-positive infections after cardiac surgery

Demographic data and comorbidities (patients, n = 65) Cardiac surgical procedure (patients, n = 65)
Age [years] Mean 60.44 ± 13,51 Aortic surgery 13 (20.0 %)
Male 57 (87.7 %) VAD implantation 14 (21.5 %)
Weight [kg] Mean 80.57 ± 14.64 Combined procedures 14 (21.5 %)
Diabetes 17 (26.2 %) CABG 8 (12.3 %)
COPD 6 (9.2 %) Isolated valve surgery 10 (15.4 %)
Rheumatic disease 1 (1.5 %) Heart transplantation 5 (7,7 %)
Hemodialysis 9 (13.8 %) CABG + CIED removal 1 (1.5 %)
Classified as multi-morbid 31(47.7 %) Classified as high-risk procedure 32 (67.7 %)
Focus of infection (courses of treatment, n = 69) Pathogens isolated (courses of treatment, n = 69)
Central venous catheter-associated infection 16 (23.2 %) Staphylococcus epidermidis 21 (30.4 %)
Valve endocarditis 13 (18.8 %) Staphylococcus aureus, MRSA 9 (13.0 %)
Sternal wound infection 9 (13.0 %) Staphylococcus aureus, MSSA 7 (10.1 %)
VAD-associated infection 8 (11.6 %) Enterococcus spp. 7 (10.1 %)
CIED-associated infection 3 (4.3 %) Other 6 (8.7 %)
Respiratory tract infection 3 (4.3 %) No causative organism identified 19 (27.5 %)
Bloodstream infection 3 (4.3 %)   
Infection of arterial lines 2 (2.9 %)   
Other infection 3 (4.3 %)   
No focus of infection identified 9 (13.0 %)   
Secondary infection (courses of treatment, n = 69) Diagnostics (courses of treatment, n = 69)
Present in 34 (49.3 %) Clinical signs and symptoms only 15 (21.7 %)
Fungal pathogen 24 (70.6 %) Positive swab/tissue sample from infection site 23 (33.3 %)
Gram-negative rods 6 (17.6 %) Positive blood culture 15 (21.7 %)
Staph. aureus 2 (5.9 %) Echocardiographic findings 13 (18.8 %)
Coagulase-negative staphylococcus 1 (2.9 %) CT findings 4 (5.8 %)
Propionibacterium acnes 1 (9.1 %) Positive culture from catheter tip 15 (21.7 %)
   Multiple diagnostics 10 (14.5 %)
Surgical/interventional measures (courses of treatment, n = 69) Classification of outcome (courses of treatment, n = 69)
Valve replacement for endocarditis 12 (17.4 %) Success 60 (87.0 %)
Wound debridement (with/without removal of foreign material, placement of drains, vacuum assisted closure) 17 (24.6 %) Failure 5 (7.2 %)
Removal of infected venous or arterial catheters 19 (27.5 %) Non-evaluable 4 (5.8 %)
Placement of drains 2 (2.9 %)