From: Daptomycin for the treatment of major gram-positive infections after cardiac surgery
Demographic data and comorbidities | (patients, n = 65) | Cardiac surgical procedure | (patients, n = 65) |
Age [years] | Mean 60.44 ± 13,51 | Aortic surgery | 13 (20.0 %) |
Male | 57 (87.7Â %) | VAD implantation | 14 (21.5Â %) |
Weight [kg] | Mean 80.57 ± 14.64 | Combined procedures | 14 (21.5 %) |
Diabetes | 17 (26.2Â %) | CABG | 8 (12.3Â %) |
COPD | 6 (9.2Â %) | Isolated valve surgery | 10 (15.4Â %) |
Rheumatic disease | 1 (1.5Â %) | Heart transplantation | 5 (7,7Â %) |
Hemodialysis | 9 (13.8 %) | CABG + CIED removal | 1 (1.5 %) |
Classified as multi-morbid | 31(47.7Â %) | Classified as high-risk procedure | 32 (67.7Â %) |
Focus of infection | (courses of treatment, n = 69) | Pathogens isolated | (courses of treatment, n = 69) |
Central venous catheter-associated infection | 16 (23.2Â %) | Staphylococcus epidermidis | 21 (30.4Â %) |
Valve endocarditis | 13 (18.8Â %) | Staphylococcus aureus, MRSA | 9 (13.0Â %) |
Sternal wound infection | 9 (13.0Â %) | Staphylococcus aureus, MSSA | 7 (10.1Â %) |
VAD-associated infection | 8 (11.6Â %) | Enterococcus spp. | 7 (10.1Â %) |
CIED-associated infection | 3 (4.3Â %) | Other | 6 (8.7Â %) |
Respiratory tract infection | 3 (4.3Â %) | No causative organism identified | 19 (27.5Â %) |
Bloodstream infection | 3 (4.3Â %) | Â | Â |
Infection of arterial lines | 2 (2.9Â %) | Â | Â |
Other infection | 3 (4.3Â %) | Â | Â |
No focus of infection identified | 9 (13.0Â %) | Â | Â |
Secondary infection | (courses of treatment, n = 69) | Diagnostics | (courses of treatment, n = 69) |
Present in | 34 (49.3Â %) | Clinical signs and symptoms only | 15 (21.7Â %) |
Fungal pathogen | 24 (70.6Â %) | Positive swab/tissue sample from infection site | 23 (33.3Â %) |
Gram-negative rods | 6 (17.6Â %) | Positive blood culture | 15 (21.7Â %) |
Staph. aureus | 2 (5.9Â %) | Echocardiographic findings | 13 (18.8Â %) |
Coagulase-negative staphylococcus | 1 (2.9Â %) | CT findings | 4 (5.8Â %) |
Propionibacterium acnes | 1 (9.1Â %) | Positive culture from catheter tip | 15 (21.7Â %) |
 |  | Multiple diagnostics | 10 (14.5 %) |
Surgical/interventional measures | (courses of treatment, n = 69) | Classification of outcome | (courses of treatment, n = 69) |
Valve replacement for endocarditis | 12 (17.4Â %) | Success | 60 (87.0Â %) |
Wound debridement (with/without removal of foreign material, placement of drains, vacuum assisted closure) | 17 (24.6Â %) | Failure | 5 (7.2Â %) |
Removal of infected venous or arterial catheters | 19 (27.5Â %) | Non-evaluable | 4 (5.8Â %) |
Placement of drains | 2 (2.9Â %) | Â | Â |