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Table 1 Summary of baseline, infection, diagnostic, treatment and outcome parameters

From: Daptomycin for the treatment of major gram-positive infections after cardiac surgery

Demographic data and comorbidities

(patients, n = 65)

Cardiac surgical procedure

(patients, n = 65)

Age [years]

Mean 60.44 ± 13,51

Aortic surgery

13 (20.0 %)

Male

57 (87.7 %)

VAD implantation

14 (21.5 %)

Weight [kg]

Mean 80.57 ± 14.64

Combined procedures

14 (21.5 %)

Diabetes

17 (26.2 %)

CABG

8 (12.3 %)

COPD

6 (9.2 %)

Isolated valve surgery

10 (15.4 %)

Rheumatic disease

1 (1.5 %)

Heart transplantation

5 (7,7 %)

Hemodialysis

9 (13.8 %)

CABG + CIED removal

1 (1.5 %)

Classified as multi-morbid

31(47.7 %)

Classified as high-risk procedure

32 (67.7 %)

Focus of infection

(courses of treatment, n = 69)

Pathogens isolated

(courses of treatment, n = 69)

Central venous catheter-associated infection

16 (23.2 %)

Staphylococcus epidermidis

21 (30.4 %)

Valve endocarditis

13 (18.8 %)

Staphylococcus aureus, MRSA

9 (13.0 %)

Sternal wound infection

9 (13.0 %)

Staphylococcus aureus, MSSA

7 (10.1 %)

VAD-associated infection

8 (11.6 %)

Enterococcus spp.

7 (10.1 %)

CIED-associated infection

3 (4.3 %)

Other

6 (8.7 %)

Respiratory tract infection

3 (4.3 %)

No causative organism identified

19 (27.5 %)

Bloodstream infection

3 (4.3 %)

  

Infection of arterial lines

2 (2.9 %)

  

Other infection

3 (4.3 %)

  

No focus of infection identified

9 (13.0 %)

  

Secondary infection

(courses of treatment, n = 69)

Diagnostics

(courses of treatment, n = 69)

Present in

34 (49.3 %)

Clinical signs and symptoms only

15 (21.7 %)

Fungal pathogen

24 (70.6 %)

Positive swab/tissue sample from infection site

23 (33.3 %)

Gram-negative rods

6 (17.6 %)

Positive blood culture

15 (21.7 %)

Staph. aureus

2 (5.9 %)

Echocardiographic findings

13 (18.8 %)

Coagulase-negative staphylococcus

1 (2.9 %)

CT findings

4 (5.8 %)

Propionibacterium acnes

1 (9.1 %)

Positive culture from catheter tip

15 (21.7 %)

  

Multiple diagnostics

10 (14.5 %)

Surgical/interventional measures

(courses of treatment, n = 69)

Classification of outcome

(courses of treatment, n = 69)

Valve replacement for endocarditis

12 (17.4 %)

Success

60 (87.0 %)

Wound debridement (with/without removal of foreign material, placement of drains, vacuum assisted closure)

17 (24.6 %)

Failure

5 (7.2 %)

Removal of infected venous or arterial catheters

19 (27.5 %)

Non-evaluable

4 (5.8 %)

Placement of drains

2 (2.9 %)

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