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Table 4 30-days survival

From: Impact of prophylactic administration of Levosimendan on short-term and long-term outcome in high-risk patients with severely reduced left-ventricular ejection fraction undergoing cardiac surgery – a retrospective analysis

 

30-days survival; n (%)

Parameter

LS +

n = 82

LS -

n = 155

p-value

All patients n = 237

69/82 (84)

123/155 (79)

0.40

Subgroup: procedural categories

Isolated CABG

26/32 (81)

58/68 (85)

0.77

Isolated valve surgery / ascending aortic surgery

11/12 (92)

23/33 (70)

0.24

Combination procedures

32/38 (84)

42/54 (78)

0.64

Subgroup analysis: renal impairment

GFR >120ml/min.

32/35 (91)

50/59 (85)

0.53

GFR 85–120ml/min.

12/13 (92)

47/55 (86)

1.00

GFR 51–85 ml/min.

17/20 (85)

19/29 (66)

0.19

GFR < 51ml/min.

5/9 (56)

4/7 (57)

1.00

Dialysis

3/5 (60)

3/5 (60)

1.00

Subgroup analysis: preoperative LVEF

LVEF <25%

29/36 (81)

46/65 (71)

0.34

LVEF 25–30%

21/23 (91)

41/48 (85)

0.60

LVEF 31–35%

19/23 (83)

36/42 (86)

0.72

Subgroup analysis: EuroSCORE II

EuroSCORE II <15

37/39 (95)

84/91 (92)

0.72

EuroSCORE II 15–17

3/4 (75)

4/5 (80)

1.00

EuroSCORE II 18–20

2/2 (100)

4/5 (80)

1.00

EuroSCORE II 21–23

4/5 (80)

3/3 (100)

1.00

EuroSCORE II >23

16/23 (70)

20/39 (51)

0.19

Subgroup analysis: Recent myocardial infarction

No recent myocardial infarction

50/55 (91)

72/87 (83)

0.22

Recent myocardial infarction

19/27 (70)

51/68 (75)

0.80

  1. 30-days survival data were available for 237/246 patients (96%). Overall, 30-days survival did not differ between patients who received prophylactic LS and patients who did not. In the subgroup analyses depending on procedural categories, renal impairment, preoperative LVEF, EuroSCORE II and recent myocardial infarction, no significant differences between LS group and control group were observed
  2. Abbreviations: CABG Coronary artery bypass grafting surgery, GFR Glomerular filtration rate, LS Levosimendan, LVEF Left-ventricular ejection fraction